摘要
血管内皮生长因子(VEGF)是特异性作用于内皮细胞糖基化的细胞有丝分裂素,增强血管的渗透性、诱导血管新生,促进肝癌细胞生长和侵袭转移,且VEGF高表达患者预后差。负性调节VEGF可明显抑制肝癌细胞恶性增生,改善患者预后。本文系统综述VEGF表达及其对与肝癌细胞侵袭转移促进作用和基于VEGF靶向药物治疗拮抗肝癌患者病灶的血管新生的最新研究进展,为延缓患者病情进展提供新思路。
Vascular endothelial growth factor ( VEGF) is a mitogen that specifically acts on glycosylated cells of endothelial cells, enhances vascular permeability, induces angiogenesis, promotes the growth, invasion and metastasis of hepatocellular carcinoma cells. The prognosis of patients with high expression of vascular endothelial growth factor is poor. Down-regulation of VEGF can significantly inhibit the malignant proliferation of hepatocellular carcinoma ( HCC ) and improve patients' prognosis. This article systematically reviewed the recent advances in VEGF expression and its role in promoting the invasion and metastasis of hepatocellular carcinoma cells as well as in VEGF-targeted anti-angiogenesis therapy for patients with HCC, aiming to provide some novel ideas to delay the disease progression in the patients.
作者
王健
李存娣
曹伟娅
Wang Jian;Li Cundi;Cao Weiya(Department of Aetiology and Immunology, Medical College, Anhui University of Science & Technology, Huainan 232001, China)
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2019年第1期73-78,共6页
Chinese Journal of Microbiology and Immunology
基金
安徽省教育厅重大自然科学研究项目(KJ2016SD20)
中国煤炭工业协会科研项目(MTKJ2015-333)
安徽省自然科学基金(1308085MH148)
安徽省2015年高等教育振兴计划项目重大教学改革研究项目(2O15zdjyO68).
关键词
血管内皮生长因子
肝癌细胞
血管新生
侵袭
转移
靶向治疗
Vascular endothelial growth factor
Hepatocellular carcinoma cell
Angiogenesis
Invasion
Metastasis
Targeted therapy
