摘要
目的分析比较广州血液中心2010～2015年对全血献血者血液标本的两种检测模式的效果。方法采用回顾性数据分析和统计学方法,对广州血液中心两种检测模式的全血献血人数、血液采集量和报废情况进行分析。结果 2010～2015年全血无偿献血者1546938人,全血献血量2381126.95U,两种检测模式下检测阳性报废率分别是5.19%和3.82%。两种检测模式对ALT、抗-HCV、梅毒抗体和核酸检测阳性率的差异有统计学意义。结论检测模式2实施期间不合格血量、报废血量和报废率均大幅度降低,尤其是ALT阳性率显著降低。ALT阳性率降低对HCV抗体和梅毒抗体阳性率降低有意义。HBsAg复检阳性率无明显变化。检测模式2是目前较高效的检测模式,能有效提高临床输血安全。建议合理进行献血前快速筛查和献血后检测项目研究,能有效降低全血的报废率,减少血液的浪费,同时大力推广2013～2015年检测模式2的实际应用。
Objective To analyze the effects of two different detection modes on the effectiveness of blood screening from 2010 to 2015. Methods The retrospective and chi-square test were used to analyze the number of donators and volumes of blood collected and discarded. Results Mode 2 composed of gold labeled fast detection for HBsAg,dry chemical method for ALT,ABO typing,physical examination of the donors,followed by re-detections of nucleic acids and antibodies to ALT,HBsAg,HCV,syphilis,HIV,and ABO blood group and RHD type etc. A total of 1 546 938 blood donors were collected . Among them,5.19% and 3.82% of blood were discarded when examined by the two modes of profile detections due to positive nucleic acids or antibodies against ALT,HBsAg,HCV,and syphilis. A significant difference of positive rates between the two modes was noted. Conclusion Mode 2 is appropriate for detection of infectious agents and effective for reduction of blood wastage.
作者
傅钰斌
汪传喜
张伟东
李仲平
黄杰庭
汤静儿
FU Yu-bin;WANG Chuan-xi;ZHANG Wei-dong(Blood Center of Guangdong Province ,Guangzhou 510095)
出处
《临床输血与检验》
CAS
2019年第2期159-161,共3页
Journal of Clinical Transfusion and Laboratory Medicine
基金
广东省广州市医药卫生科技一般引导项目(No.20161A010071)
国家自然科学基金青年项目(No.81402733)
广东省广州市科创委协同创新重大专项(No.158100065)资助
关键词
全血
无偿献血
检测模式
阳性率
Whole blood
Blood donation
Detection model
Positive rate
