摘要
目的探讨高龄孕妇羊水胎儿核型异常情况。方法对2013-07～2018-09来我院进行产前诊断的2 793例高龄孕妇的羊水细胞检查结果,通过检查指征以及核型结果进行统计分析。结果 2 793例高龄孕妇中检出染色体异常183例,异常检出率是6. 6%。其中21三体及其嵌合体118例,18三体18例,13三体2例,性染色体异常29例,结构异常14例,衍生染色体3例,标记染色体2例。结论高龄孕妇胎儿异常检出率高,故高龄及高龄合并其他高危因素的孕妇及时进行产前诊断及遗传咨询十分必要,以减少染色体异常的出生缺陷率。
Objective To explore fetal karyotype abnormalities of older pregnant women’s amniotic fluid.Methods Amniotic fluid results of 2 793 pregnant women of advanced maternal age from July 2013 to September 2018 in our hospital for prenatal diagnosis were analyzed.Results A total of 183 chromosomal abnormalities were detected in older women,and the abnormal detection rate was 6.6%.Among them,there were 120 cases of trisomy 21 and its chimera,18 cases of 18 trisomy,2 cases of trisomy 13,2 cases of sex chromosome abnormality,14 cases of structural abnormality,3 cases of derived chromosome,and 2 cases of marker chromosome.Conclusion The detection rate of fetal abnormality is very high in pregnant women of advanced maternal age.Therefore,the timely prenatal diagnosis and the genetic counseling are necessary for the pregnant women of advanced maternal age with other risk factors to reduce the birth defect rate of chromosomal abnormalities.
作者
郑娇
程璐
李春艳
徐慧
唐苗苗
徐盈
陈必良
张建芳
ZHENG Jiao;CHENG Lu;LI Chunyan;XU Hui;TANG Miaomiao;XU Ying;CHEN Biliang;ZHANG Jianfang(Department of Obstetrics and Gynecology,First Affiliated Hospital of Air Force Military Medical University,Xi’an 710032,China)
出处
《山西医科大学学报》
CAS
2019年第3期354-356,共3页
Journal of Shanxi Medical University
关键词
高龄
产前诊断
羊水细胞
染色体核型分析
advanced maternal age
prenatal diagnosis
amniotic fluid
karyotype analysis
