摘要
食品和饲料若加工、贮藏不当易产生大分子蛋白毒素和小分子毒素。许多研究者在食品和饲料中开始采用添加营养成分的方式来降低毒素毒性和预防其诱发疾病。卵黄抗体具有与抗原特异性结合的生物学特性,作为营养添加剂在中和毒素、治疗病毒和细菌性疾病等方面已得到广泛的应用。本文主要对卵黄抗体活性影响因素、体内代谢和中和蛋白大分子毒素等方面的研究进展以及发挥保护作用机制方面进行综述,最后分析讨论了卵黄抗体对小分子毒素的降毒效应研究现状和应用前景。抗毒素卵黄抗体有望被开发成口服解毒制剂,为降低食品和饲料中毒素毒性增添新的途径。
Improper food processing or storage is associated with the production of macromolecular protein toxins and small molecular toxins.Nowadays,there is an increasing interest in nutritional supplements that may counteract the detrimental effects of toxic compounds and prevent multiple diseases in humans.Egg yolk immunoglobulin(IgY)as a nutraceutical supplement for therapeutic and prophylactic intervention and against macromolecular protein toxins has been extensively studied.This article reviews recent progress in the factors affecting IgY activity,its metabolism and application for the neutralization of macromolecular protein toxins as well as the underlying mechanism.Meanwhile,we discuss the current status of understanding the detoxifying effect of IgY on small molecular toxins and future prospects for its application in this area.IgY has potential application in food and feed as an oral detoxicant.
作者
邱涛涛
徐振林
甘庆庆
王兰腾
沈兴
李向梅
孙远明
雷红涛
QIU Taotao;XU Zhenlin;GAN Qingqing;WANG Lanteng;SHEN Xing;LI Xiangmei;SUN Yuanming;LEI Hongtao(Key Laboratory of Food Quality and Safety of Guangdong Province,College of Food Science,South China Agricultural University,Guangzhou 510642,China)
出处
《食品科学》
EI
CAS
CSCD
北大核心
2019年第5期303-308,共6页
Food Science
基金
国家自然科学基金面上项目(31871883)
国家自然科学基金重点项目(71633002)
广州市科技计划项目(2017B020207010
2016201604030004
20162017LM2152)
关键词
卵黄抗体
体内代谢
中和作用
大分子蛋白毒素
egg yolk immunoglobulin
metabolism
neutralization
macromolecular protein toxins
