摘要
目的:探讨FEZ1蛋白在宫颈小细胞癌及其他宫颈癌或病变组织的表达。方法:选取选取2010年1月至2016年1月中山大学肿瘤防治中心诊治的25例宫颈小细胞癌作为观察组,并选择同期诊治的25例宫颈其他类型恶性肿瘤作为第一对照组,25例CINⅢ作为第二对照组,25例宫颈慢性炎作为第三对照组。采用免疫组织化学法分别检测FEZ1蛋白在观察组及各对照组的表达情况并分析其差异,进一步探讨FEZ1蛋白表达水平与宫颈小细胞癌及宫颈其他类型恶性肿瘤患者临床病理特征关系。结果:FEZ1蛋白在宫颈小细胞癌中的阳性表达率(8.0%)低于其他三个对照组[宫颈其他类型恶性肿瘤组(40.0%)、CINⅢ组(48.0%)及宫颈慢性炎组(60.0%),P<0.05]。淋巴结转移组FEZ1蛋白阳性表达例数明显少于无淋巴结转移组,差异有统计学意义(P<0.05)。结论:宫颈小细胞癌组织中FEZ1蛋白的表达水平极低,且与淋巴结转移相关,提示FEZ1蛋白表达缺失或下调可能与宫颈小细胞癌的发生发展有关,FEZ1蛋白可能成为宫颈小细胞癌病理诊断的免疫组织化学指标之一。
Objective: To investigate the relationship of FEZ1 protein level and the clinicopathologic features in small cell cervical carcinoma and other types of cervical carcinoma. Methods: Twenty-five cases of small cell cervical carcinoma from cancer control center of sun yat-sen university were recruited as study group, 25 cases of other types of cervical carcinoma were collected as the first control group, 25 cases of CINⅢ were as the second control group, and 25 cases of chronic cervicitis were as the third control group. All patients in study and control group were treated at the same period. The immunohistochemistry (IHC) analysis method was performed to detect the expression of FEZ1 protein in the study group and the control group. The differences of FEZ1 protein in study and control groups, and the correlations of FEZ1 protein level and the clinicopathologic features were analyzed. Results: The positive rate of FEZ1 protein in small cell cervical carcinoma group(8.0 %) was significantly lower than that in all three control groups(40.0 %,48.0 %,60.0 %, P <0.05). And the positive rate of FEZ1 protein in patients with the lymph node metastasis was also dramatically lower than that in patients without lymph node metastasis( P <0.05). Conclusion: The expression of FEZ1 protein was extremely low in small cell cervical carcinoma compared with other cervical carcinoma. It indicates that the loss of FEZ1 protein may be correlated with the tumorigenecity and lymph node metastasis of small cell cervical carcinoma. Moreover, FEZ1 protein may be another histologic marker for pathological diagnosis.
作者
庄圆
邓鹏飞
李俊东
ZHUANG Yuan;DENG Pengfei;LI Jundong(The Fifth Affiliated Hospital,Sun Yat-sen University,Zhuhai 519000,China;Zhuhai People's Hospital of Guangdong Province;Cancer Center of Sun Yat-sen University)
出处
《包头医学院学报》
CAS
2019年第2期26-28,共3页
Journal of Baotou Medical College
关键词
FEZ1蛋白
宫颈小细胞癌
免疫组织化学
Fasciculation and elongation protein zeta-1(FEZ1)
Small cell cervical carcinoma
Immunohistochemistry (IHC)
