摘要
目的研究地尔硫卓联合小剂量地高辛治疗心力衰竭的疗效。方法选择心力衰竭患者98例,随机分为单一组与联合组,各49例。在常规抗心衰治疗的同时,单一组:地高辛(0.25 mg/次,1次/d);联合组:小剂量地高辛(0.125 mg/次,1次/d)+地尔硫卓(30 mg/次,3次/d)。比较两组治疗后临床疗效以及治疗前后心功能[左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)]及血清学指标[血清中缺血修饰白蛋白(IMA)、肌钙蛋白I(cTnI)、肌酸激酶同功酶(CK-MB)水平]的变化。结果治疗后,联合组总有效率为89.90%,高于单一组的75.51%(P <0.05);治疗后,两组LVEF、LVEDD、LVESD水平较治疗前均改善(P <0.05),血清IMA、c TnI、CK-MB水平较治疗前均降低(P <.05),且联合组改善或降低幅度均大于单一组(P <0.05)。结论地尔硫卓联合小剂量地高辛治疗对心力衰竭患者疗效确切,可在减少地高辛用量的情况下,减轻心肌损伤程度,改善心功能,提高治疗效果。
Objective To study the efficacy of diltiazem combined with low-dose digoxin in the treatment of heart failure.Methods A total of 98 patients with heart failure were randomly divided into a single group and a combined group(n=49,respectively).On the basis of routine anti-heart failure treatment,the single group was additionally given digoxin(0.25 mg/time,once a day)while the combined group was given low-dose digoxin(0.125 mg/time,once a day)+diltiazem(30 mg/time,three times a day).The clinical efficacy and changes of cardiac functions[left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD)and left ventricular end systolic diameter(LVESD)]and serological indexes[ischemic modified albumin(IMA),cardiac troponin I(cTnI)and creatine kinase isoenzyme(CK-MB)]before and after the treatment were compared between the two groups.Results After the treatment,the total effective rate of the combined group was 89.90%,higher than that(75.51%)of the single group(P<0.05);the levels of LVEF,LVEDD and LVESD in both groups were improved(P<0.05),and the levels of serum IMA,cTnl and CK-MB decreased(P<0.05)and the improvement or reduction of the combined group was greater than that of the single group(P<0.05).Conclusion Diltiazem combined with low-dose digoxin is effective in the treatment of heart failure.It can reduce the dosage of digoxin,reduce the degree of myocardial injury,improve cardiac functions and improve the therapeutic effects.
作者
贺孝和
He Xiaohe(Department of Cardiovascular Medicine,Chengdu Tianfu New District People's Hospital,Chengdu,Sichuan,610213,China)
出处
《西南国防医药》
CAS
2019年第3期321-323,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
地尔硫卓
地高辛
心力衰竭
疗效
diltiazem
digoxin
heart failure
therapeutic effect
