摘要
目的探讨右美托咪定在儿童脊髓栓系综合征(TCS)手术全身麻醉维持中,对机体正常呼吸及循环功能的维持作用。方法选择2018年9月25日,因"发现骶尾部包块3^+个月",于四川大学华西医院进行手术治疗时,采取右美托咪定进行麻醉维持的1例TCS患儿为研究对象。采用回顾性分析方法,收集该例患儿的临床病例资料,对其手术麻醉维持方案及其效果进行总结。对儿童TCS手术麻醉维持相关文献进行复习时,设定检索策略为:分别以"脊髓栓系综合征""儿童""麻醉""tethered cord syndrome""pediatric"及"anesthesia"为中、英文关键词,在PubMed数据库、EMBASE数据库、中国生物医学文献服务系统(SinoMed)、中国知网(CNKI)、万方数据知识服务平台、维普中文科技期刊数据库中,检索儿童TCS手术麻醉维持相关文献,检索时间设定为2007年1月1日至2018年10月1日。本研究遵循的程序符合2013年修订的《世界医学协会赫尔辛基宣言》要求。结果①病史采集及辅助检查结果:本例患儿为男性,3^+个月龄,发现骶尾部包块3^+个月,其他发育正常。MRI检查结果显示,骶管增粗,L4至S3平面骶管后部可见梭形脂肪信号影(4.0 cm×1.2 cm×1.3 cm)。②手术治疗方案:对本例TCS患儿进行脊髓黏连松解术+椎管内外巨大占位切除术,采用术中神经电生理监测(IONM)技术,对患儿运动诱发电位(MEP)、肌电图进行监测。③手术麻醉诱导及维持方案:对本例患儿TCS手术采取8%七氟烷潮气量法,并静脉注射舒芬太尼5μg、顺阿曲库铵2 mg进行麻醉诱导。同时,采用静脉注射右美托咪定0.5～1.0μg/(kg·min)联合瑞芬太尼0.15～0.20μg/(kg·min)进行麻醉维持,麻醉维持时间为5.1 h。患儿术后未发生低血压、心率降低等不良反应,拔管顺利,术后第4天顺利出院。④文献复习结果:按照本研究设定的文献检索策略,共计检索出5篇文献报道儿童TCS手术麻醉维持方案,涉及277�
Objective To explore the effects of dexmedetomidine on maintaining the normal breathing and circulatory functions during pediatric tethered cord syndrome (TCS) surgery with general anesthesia maintenance. Methods On September 25, 2018, a child with TCS and discovery of sacrococcygeal mass for 3 + months who underwent surgical treatment with dexmedetomidine for anesthesia maintenance in West China Hospital of Sichuan University was selected as research subject. A retrospective analysis was conducted to collect the clinical data of the patient, summarize the anesthesia maintenance plan during operation and its effects. When reviewing literatures related to anesthesia maintenance in pediatric TCS surgery, the strategies of literature retrieval were set as follows. With the keywords of "tethered cord syndrome""pediatric" and "anesthesia" both in Chinese and English, literatures related to anesthesia maintenance of pediatric TCS surgery were searched from PubMed database, EMBASE database, SinoMed, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform and VIP database. The retrieval time was set from January 1, 2007 to October 1, 2018. The procedure followed in this study met the requirements of the World Medical Association Declaration of Helsinki revised in 2013. Results ①Medical history collection and auxiliary examination results: this child was male, 3 + months old, with discovery of sacrococcygeal mass 3 + months and without other abnormal development. The results of MRI showed that his sacral canal was enlarged and spindle fat signal was found in the posterior part of the sacral canal from L4 to S3 planes, which was about 4.0 cm × 1.2 cm × 1.3 cm.②Surgical treatment: this child with TCS received the treatment of spinal cord adhesiolysis and resection of giant space occupying both inside and outside the spinal canal. Intraoperative neurophysiological monitoring (IONM) technique was used during the operation to monitor the motor evoked potential (MEP) and electromyogram of t
作者
杨进坤
李羽
Yang Jinkun;Li Yu(Department of Anesthesiology,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China)
出处
《中华妇幼临床医学杂志（电子版）》
CAS
2019年第1期63-67,共5页
Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
基金
四川省科技厅重点研发项目(2018SZ0217)~~
关键词
右美托咪定
神经管缺损
脊髓栓系综合征
麻醉苏醒延迟
监测
生理学
术中神经电生理监测
儿童
Dexmedetomidine
Neural tube defects
Tethered cord syndrome
Delayed emergence from anesthesia
Monitoring, physiologic
Intraoperative neurophysiological monitoring
Child
