摘要
目的分析丙型肝炎核心抗原(HCV-cAg)与抗体(抗-HCV IgG)联合检测在丙肝感染早期诊断中的应用价值。方法将2015年2月～2017年5月医院各科室有丙肝高危感染风险的296例患者作为观察对象,所有患者取血清进行HCV-cAg和抗-HCV、ALT、TBil检查,以HCV-RNA检测结果为金标准,观察不同检查方法诊断的患者HCV感染情况,分析HCV-cAg、抗-HCV IgG联合用于疾病早期诊断的有效性。结果 HCV-RNA含量与ALT水平成正相关(r=0.978,P<0.05),HCV-RNA含量与Tbil水平无相关性(r=-0.681,P>0.05);抗-HCV IgG方法的检出率为69.1%,HCV-cAg方法为82.3%,血清肝功能检测方法为58.2%,HCV-cAg方法的检出率高于抗-HCV IgG方法、血清肝功能检测方法(P<0.05)。抗-HCV IgG、HCV-cAg联合检出率最高,为96.5%,显著高于HCV-cAg、血清肝功能联合监测的90.9%,抗-HCV IgG、血清肝功能联合检测的74.5%,差异有统计学意义(P<0.05);HCV-cAg、抗-HCV IgG联合检测的诊断价值高于单指标检查。结论抗-HCV IgG、HCV-cAg联合用于HCV早期感染诊断,临床检出率高。
Objective To analyze the application value of HCV-core antigen(HCV-cAg)and anti-HCV-immunoglobulin G(anti-HCV IgG)for joint detection in early diagnosis of hepatitis C infection.Methods All of 296 patients with high risks of HCV infection checked from February 2015 to May 2017 in each department were selected as observation objects.All the patients received the HCV-cAg,anti-HCV,alanine aminotransferase(ALT)and total bilirubin(TBil)examinations.HCV-RNA test results were used as the gold standard to observe the HCV infection of patients diagnosed by different methods,and to analyze the effectiveness of combined use of HCV-cAg and anti-HCV IgG in early diagnosis of diseases.Results HCV-RNA content was positively correlated with ALT level(r=0.978,P<0.05),while HCV-RNA content was not correlated with Tbil level(r=0.681,P>0.05).The detection rate of anti-HCV IgG,HCV-cAg and serum liver function was 69.1%,82.3%and 58.2%respectively,and the detection rates of HCV-cAg was higher than that of anti-HCV IgG and serum liver function(P<0.05).The joint detection rate of anti-HCV IgG and HCV-cAg was the highest(96.5%),which was significantly higher than that of combined monitoring of HCV-cAg and serum liver function(90.9%),the combined detection of anti-HCV IgG and serum liver function(74.5%)had statistical difference(P<0.05).The diagnostic value of combined detection of HCV-cAg and anti-HCV IgG was higher than that of single index examination.Conclusion Combination of anti-HCV IgG and HCV-cAg for early diagnosis of HCV infection has a high clinical detection rate.
作者
王爱兰
倪永圣
冼洁能
和仕进
何思杰
黄翠芳
晏文芬
WANG Ai-lan;NI Yong-sheng;XIAN Jie-neng;HE Shi-jin;HE Si-jie;HUANG Cui-fang;YAN Wen-fen(Department of Clinical Laboratory,Nanhai Hospital of Southern Medical University in Foshan City,Guangdong Province,Foshan 528244,China)
出处
《中国当代医药》
2019年第6期127-129,136,共4页
China Modern Medicine
基金
广东省佛山市"十三五"医学重点专科建设项目(FSZDZK135045)
广东省佛山市南海区"十三五"医学重点专科建设项目
关键词
早期感染
抗原
丙型肝炎
抗体
联合检测
Early infection
Antigen
Hepatitis C
Antibody
Joint detection
