摘要
肠道菌群与人类健康和疾病的影响已经成为近年来研究工作者们关注的焦点,"菌群-肠-脑"轴的存在,使肠道菌群有效参与调控着机体的复杂的生理过程,而神经-免疫-内分泌系统的精密协调,使得肠道菌群进一步参与了中枢神经系统的调控,这已经在分子生物学中得到证实。患者如果长期处于抑郁状态,不但精神心理上备受摧残,而且机体功能也将受到严重影响,包括神经系统受损,内分泌功能紊乱,甚至还会造成肠道黏膜屏障功能的严重破坏,影响身心健康。研究发现肠道菌群失调与抑郁症有密切关系,补充肠道益生菌、调节肠道菌群可以改善抑郁状态。
The influence of intestinal flora and human health and disease has become a hot spot of research in recent years,More and more molecular biological evidence reveals that the intestinal microbial community not only participates in and regulates the physiological functions of the body,but also plays a important role in the regulation of higher nervous activity through the"Flora-gut-brain"axis,which plays the role through neural immuno endocrine network regulation.The long-term depression of patients with depression can cause some damage to the body's nervous system,the endocrine system and the intestinal mucosal barrier function.The experimental study found that depression has a close relationship with intestinal microflora,while regulating intestinal flora and supplementing intestinal probiotics can improve depression.Therefore,we review the progress in the study of the correlation between intestinal flora and depression,looking for new targets for the treatment of depression.
作者
黄小群
廖小平
HUANG Xiaoqun;LIAO Xiaoping(Department of Internal Medicine,Anting Hospital,Jiading District,Shanghai 201805,China)
出处
《中国实用神经疾病杂志》
2019年第1期112-116,共5页
Chinese Journal of Practical Nervous Diseases
关键词
肠道菌群
抑郁症
“菌群肠脑”轴
益生菌
卒中后抑郁
双歧杆菌
中枢神经系统
Intestinal microflora
Depression
"Flora gut brain"axis
Probiotics
Post-stroke depression
Bifidobacterium
Central nervous system
