摘要
酒精性肝病的发病机制一直不明确,主要原因之一是现有的研究中始终缺乏精准合适的动物模型来模拟整个疾病病程。在探究酒精性肝病发病机制以及可能的治疗措施过程中,已经构建过多种不同的动物模型来模拟酒精性肝病,但都存在利弊。其中Gao-Binge模型因为更接近人类饮酒模式而受到业界广泛认可及应用,通过该模型研究发病机制和探寻潜在治疗药物更具说服力。Gao-Binge模型具有造模周期短、成本低、重复性好的优势,尽管存在一些局限性,如无法模拟酒精性肝病更严重的疾病进程,但是该模型在酒精性肝病研究中的价值毋庸置疑,而且在研究酒精导致其他器官损伤(包括心脏、胰腺)以及脂肪组织损伤中亦前景广阔。
The pathogenesis of alcoholic liver disease remains unclear, mainly due to the lack of accurate animal models in experiments. Many different animal models have been established to mimic alcoholic liver disease in patients, which have both advantages and disadvantages. Among these models, the Gao-Binge model is widely used in the experiments because it highly mimics the drinking pattern in patients. It is more persuasive that the pathogenesis and therapeutic drugs have been examined in the Gao-Bingemodel. Although there are some limits in the Gao-Binge model, it is no doubt that this model has high value and future prospect in the study of alcoholic liver disease because of short duration time, low cost and good repeatability. Finally, the Gao-Binge model has also been used to study alcohol-induced damage to other organs such as the heart, pancreas, adipose tissue etc.
作者
周珂
王华
ZHOU Ke;WANG Hua(School of Pharmacy, Institute of Liver Diseases, Anhui Medical University, Hefei 230032, China)
出处
《临床肝胆病杂志》
CAS
北大核心
2019年第3期485-488,共4页
Journal of Clinical Hepatology
基金
国家自然科学基金优秀青年基金(81522009/H0317)
国家自然科学基金上项目(81770588/H0315)
