摘要
目的观察足三里穴位注射胎盘多肽注射液对中晚期非小细胞肺癌(NSCLC)化疗患者免疫功能及骨髓抑制的疗效。方法将符合纳入标准的80例中晚期NSCLC患者随机分为治疗组(n=40)和对照组(n=40)。对照组给予常规化疗方案治疗,治疗组在常规化疗方案基础上,联合使用足三里穴位注射胎盘多肽注射液,21 d为1个治疗周期,连续治疗2个周期。治疗后比较2组患者的免疫指标、骨髓抑制、近期疗效和生存质量。结果治疗组CD^(3+)、CD^(3+)CD^(4+)比例及CD^(4+)/CD^(8+)比值明显高于对照组(P<0.05),CD^(3+)/CD^(8+)比例明显低于对照组(P<0.05);治疗组白细胞(WBC)、中性粒细胞(NEU)、红血蛋白(HGB)、血小板(PLT)减少程度均明显小于对照组(P<0.05);治疗组瘤体大小近期有效率和控制率与对照组相比,无统计学差异(P>0.05);治疗组卡氏(KPS)评分总稳定率明显高于对照组(P<0.05)。结论中晚期非小细胞肺癌患者在化疗期间,联合使用足三里穴位注射胎盘多肽注射液,能较好地保护机体免疫功能,减轻化疗引起的骨髓抑制及改善患者的生存质量。
Objective To observe the efficacy of immune function and myelosuppression of the patients with advanced non-small cell lung cancer(NSCLC)in chemotherapy by placenta polypeptide injection in the Zusanli(ST36).Methods 80 patients with advanced NSCLC who met the inclusion criteria were randomly divided into treatment group(n=40)and control group(n=40).The control group was given conventional chemotherapy treatment,and the treatment group applied injection of Zusanli(ST36)with placenta polypeptide injection on the basis of conventional chemotherapy.There are 21 days for a treatment cycle.The observation includes 2 treatment cycles.After treatment,immune index,bone marrow suppression,the recent curative effect and quality of life was compared.Results The proportion of CD3^+,CD3^+CD4^+and the ratio of CD4^+/CD8^+in the treatment group was significantly higher than that of the control group(P<0.05),and the proportion of CD3^+/CD8^+in the treatment group was significantly lower than the control(P<0.05).The reduction of white blood cells(WBC),neutrophils(NEU),hemoglobin(HGB),and blood platelet(PLT)in the treatment group was significantly smaller than that of the control group.The short-term efficiency and control rate of tumor size in the treatment group were not statistically different from those in the control group(P>0.05).The index of stability of karnofsky performance status(KPS)of the treatment group was obviously higher than the control group.Conclusion During chemotherapy of the patients with advanced non-small cell lung cancer,the combination of Zusanli(ST36)placental polypeptide injection can better protect the immune function of the body,reduce the inhibition of bone marrow caused by chemotherapy and improve the quality of life of the patients.
作者
邓维
杨柳柳
张伟
DENG Wei;YANG Liuliu;ZHANG Wei(Department of Traditional Chinese Medicine,Community Service Centre of Beijing Street in Yuexiu District,Guangdong Province,Guangzhou 510030,China;Respiratory Department,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangdong Province,Guangzhou 510405,China)
出处
《中国中医药现代远程教育》
2019年第4期69-72,共4页
Chinese Medicine Modern Distance Education of China
关键词
非小细胞肺癌
免疫功能
骨髓抑制
胎盘多肽注射液
足三里穴
咳喘
non-small cell lung cancer
immunity
myelosuppression
placental polypeptide injection
Zusanli(ST36)
cough and dyspnea
