摘要
目的探讨幽门螺杆菌(Hp)感染对2型糖尿病患者炎症因子、胃肠激素及胰岛素抵抗的影响。方法收集2014年5月至2016年10月该院收治86例2型糖尿病患者作为研究对象,患者入院后均实施13 C尿素呼气试验,依据试验结果将46例2型糖尿病伴有Hp感染者作为观察组和2型糖尿病无Hp感染者作为对照组,比较两组炎症因子超敏C反应蛋白(hs-CRP)、血清白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)和胃肠激素血清胃泌素(GAS)、生长抑素(SS)及空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR),并探讨各观察指标与Hp感染相关性分析性。结果观察组hs-CRP、IL-6、TNF-α、GAS水平及FPG、FINS、HOMA-IR较对照组明显高,而SS较对照组明显降低,差异有统计学意义(P<0.05);经进一步Sperman相关性分析显示hs-CRP、IL-6、TNF-α、GAS、FINS、HOMA-IR与Hp感染呈明显正相关(r=0.452、0.350、0.398、0.389、0.421、0.568,P<0.05),SS与Hp感染呈明显负相关(r=-0.401,P<0.05)。结论 Hp感染与2型糖尿病患者炎性反应、胃肠激素紊乱和胰岛素抵抗紧密相关,临床据此为患者实施合理的防治措施是延缓2型糖尿病疾病进展和恶化的关键。
Objective To investigate the effect of Hp infection on the inflammatory factors,gastrointestinal hormones and insulin resistance in patients with type 2 diabetes mellitus.Methods A total of 86 patients with type 2 diabetes mellitus treated in a hospital from May 2014 to October 2016 were enrolled in the study.All patients underwent 13 C urea breath test after admission,and according to the test results,patients were divided into the observation group,which was type 2 diabetes mellitus with Hp infection(n=46)and the control group,which was type 2 diabetes mellitus without Hp infection(n=40).Inflammatory factors such as high-sensitivity C reactive protein(hs-CRP),serum interleukin 6(IL-6),tumor necrosis factorα(TNF-α),gastrointestinal hormones such as serum gastrin(GAS),somatostatin(SS)and fasting blood glucose(FPG),fasting insulin(FINS),insulin resistance index(HOMA-IR)were compared between the two groups,and the correlation of the observation indicators with Hp infection was explored.Results Levels of hs-CRP,IL-6,TNF-αand GAS,FPG,FINS and HOMA-IR in the observation group were significantly higher than those in the control group,while SS was significantly lower than that in the control group,the difference was statistically significant(P﹤0.05).Further Sperman correlation analysis showed that hs-CRP,IL-6,TNF-α,GAS,FINS and HOMA-IR were positively correlated with Hp infection(r=0.452,0.350,0.398,0.389,0.421,0.568,P﹤0.05),and SS was negatively correlated with Hp infection(r=-0.401,P﹤0.05).Conclusion Hp infection is closely related to inflammatory reactions,gastrointestinal hormone disorders and insulin resistance in patients with type 2 diabetes mellitus,and taking reasonable preventive measures is the key to delay the progression and deterioration of type 2 diabetes mellitus.
作者
刘方方
马平
邓涛
LIU Fangfang;MA Ping;DENG Tao(Department of Clinical Laboratory,Central Hospital of Suizhou,Suizhou,Hubei 441300,China)
出处
《国际检验医学杂志》
CAS
2019年第4期438-440,444,共4页
International Journal of Laboratory Medicine
关键词
2型糖尿病
HP感染
炎症因子
胃肠激素
胰岛素抵抗
type 2 diabetes mellitus
Hp infection
inflammatory factors
gastrointestinal hormones
insulin resistance
