摘要
目的探讨血清肌钙蛋白(Cardiac troponinⅠ,cTn-Ⅰ)含量变化与急性脑出血(Acute cerebral hemor-rhage,ACH)的关系。方法选取2015年1月～2016年12月于我院诊治的68例ACH患者设为观察组,50例健康体检人员设为对照组,采用酶联免疫吸附试验(ELISA)检测发病24小时及3、7、14天血清cTn-Ⅰ水平,根据神经功能受损程度(National institutesof health stroke scale,NIHSS)评价神经功能障碍,比较不同神经功能障碍、不同出血量患者各时间点血清cTn-Ⅰ水平,并进行相关性分析。结果观察组发病24小时及3、7、14天血清cTn-Ⅰ水平差异均有统计学意义(P<0.05),且各时间点CTn-1水平均显著高于对照组,差异均有统计学意义(P<0.05);不同神经功能障碍、不同出血量患者各时间点血清cTn-Ⅰ水平差异均有统计学意义(P<0.05);血清cTn-Ⅰ水平与NHISS评分、出血量均呈正相关(r=0.764,P<0.001,r=0.654,P<0.001)。结论 ACH患者发病后血清cTn-Ⅰ水平显著上升,且与神经功能障碍、出血量呈正相关关系;血清cTn-Ⅰ水平可作为早期ACH病变的重要监测指标。
Objective To investigate the relationship between the changes of serum cardiac troponin content(cTnI)and acute cerebral hemorrhage(ACH).Methods 68 ACH patients and 50 healthy people in our hospital from January2015 to December 2016 were included into the observation group and the control group,respectively.Enzyme linked immunosorbent assay(ELISA)was used to detect the level of serum cTn-I.National institutes of health stroke scale(NIHSS)was used to evaluate neurological dysfunction.The levels of serum cTn-I in patients with different levels of neurological dysfunction and different amount of blood loss were compared and analyzed.Results The serum cTn-I levels after the onset of 24 h,3 D,7 d,14 din the observation group were statistically significant(P<0.05);The level of serum cTnI in the observation group was significantly higher than that in the control group at each time point,and the difference was statistically significant(P<0.05).There were significant differences in serum cTn-I levels at different time points in patients with different levels of neurological disorders(P<0.05).There were significant differences in serum cTn-I levels at different time points in patients with different amount of blood loss(P<0.05).Serum cTn-I level was positively correlated with NHISS score and blood loss(r=0.764,P<0.001,r=0.654,P<0.001).Conclusion The level of serum cTn-I is increased significantly in patients with ACH,which is positively correlated with neurological disorders and blood loss,so it can be used as an important indicator of early myocardial injury in patients with ACH.
作者
谢成金
黄进兴
刘光普
XIE Chengjin;HUANG Jinxing;LIU Guangpu(The Second Department of Neurosurgery,Meizhou People's Hospital,Meizhou 514031,Guangdong,China)
出处
《西部医学》
2019年第2期287-290,共4页
Medical Journal of West China
基金
广东省医学科研基金项目(A2014725)
关键词
血清肌钙蛋白
急性脑出血
神经功能
出血量
Serum cardiac troponin Ⅰ
Acute cerebral hemorrhage
Neurological function
Amount of bleeding
