摘要
目的探讨不同的手术切除方法对胃恶性肿瘤患者血浆及血清中IL-6,TNF-α浓度的影响及预后。方法随机选择80例胃恶性肿瘤患者,并按随机抽样法分为对照组和观察组,各40例。对照组患者采用开放手术方案;观察组采用腹腔镜下胃癌根治术手术方案。记录患者的手术情况及术后恢复情况,统计患者治疗过程中的有效率及密切观察并记录患者IL-6,TNF-α的浓度。结果观察组术中出血量[(167. 82±17. 43) ml]、卧床时间[(19. 68±2. 41) h]及胃肠道功能恢复时间[(41. 67±4. 46) h]明显低于对照组术中出血量[(218. 54±16. 17) ml]、卧床时间[(24. 18±2. 33) h]及胃肠道功能恢复时间[(48. 16±4. 17) h],手术时间[(194. 24±12. 46) min]多于对照组手术时间[(157. 56±12. 19)min],差异均有统计学意义(P <0. 05)。治疗前,2组患者血清及血浆中的IL-6,TNF-α含量无明显差别;术后7 d,2组患者的血清及血浆中的IL-6,TNF-α含量均明显降低,但观察组的血清及血浆中的IL-6,TNF-α含量明显低于对照组,差异有统计学意义(P <0. 05)。观察组治疗的有效率(90. 00%)优于对照组治疗的有效率(82. 50%),差异有统计学意义(P<0. 05)。观察组术后并发症总发生率(5. 00%)低于对照组的总发生率(12. 50%),差异有统计学意义(P <0. 05)。结论采用腹腔镜下胃癌根治术手术切除胃恶性肿瘤,能有效改善患者血清及血浆中IL-6及TNF-α含量,提高治疗有效率,值得临床参考。
Objective To explore the concentration and prognostic risk factors of IL-6 and TNF-in plasma and serum of patients with gastrointestinal tumor by different surgical resection methods.Methods 80 patients with gastrointestinal carcinoma were randomly selected in our hospital.They were randomly divided into the control group and the observation group,each with 40 cases.The control group were treated with laparoscopic surgery,while the observation group received laparoscopic combined endoscopic surgery.The operation and postoperative recovery of the patients were recorded,the effective rate of the patients during the treatment and the prognostic factors of the patients were observed and recorded.Results The amount of intraoperative bleeding[(167.82±17.43)ml],bed time[(19.68±2.41)h]and gastrointestinal function recovery time[(41.67±4.46)h]was significantly lower than the control group blood loss[(218.54±16.17)ml],bed time[(24.18±2.33)h]and the recovery time of gastrointestinal function[(48.16±4.17)h],operation time[(194.24±12.46)min]more than the control group operation time[(157.56±12.19)min],the difference was statistically significant(P<0.05).Before treatment,2 groups of patients in serum and plasma IL-6,no significant difference of TNF-αcontent;7 d after operation,serum and plasma of patients in the 2 groups in IL-6,TNF-αcontent was decreased,but the IL-6,TNF-αof the serum and plasma in the observation group was significantly lower than the control group,the difference was statistically statistically significant(P<0.05).The effective rate of the observation group was(90.00%)better than that of the control group(82.50%),but the difference was statistically significant(P<0.05).The total incidence rate of risk factors in the observation group was(5.00%),which was better than that of the control group(12.50%),but the difference was statistically significant(P<0.05).Conclusion Laparoscopic resection combined with endoscopic resection of gastrointestinal tract tumor can effectively improve the serum and plasm
作者
朱大刚
ZHU Dagang(Changzhou Wujin People's Hospital,Changzhou,213102)
出处
《实用癌症杂志》
2019年第2期275-277,292,共4页
The Practical Journal of Cancer
关键词
不同手术方式
胃恶性肿瘤
IL-6
TNF-Α
预后
Different surgical approaches
Gastrointestinal neoplasms
IL-6
TNF-α
Prognostic risk factors
