摘要
海洋微生物生活在高盐、高压、低温、低营养或无光照等特殊生境,造就了其种类的多样性和特殊性,能产生海洋微生物所特有的结构新颖、作用特殊的生物活性物质。在海洋微生物中放线菌具有较为复杂的发育分化过程,还能产生大量次级代谢产物。该文综述了近年来从海洋放线菌中筛选天然活性化合物的有效方法,包括优化培养基,改进培养方法和检测技术,运用基因组挖掘技术等。这些有效方法的运用使得从海洋放线菌中筛选生物活性物质具有广阔的开发应用前景。
Marine microorganisms live in special habitats such as high salt, high pressure, low temperature, oligotrophic or no light, which resulted in the diversity and specificity of their species, and can produce the marine derived bioactive compounds with novel chemical structure and specific functions. Among marine microorganism, Actinomycetes have a relatively complex process of development and differentiation, and can also produce a great variety of secondary metabolites. The effective methods of screening natural active compounds i^om marine Actinomycetes in recent years,including optimizing the medium, improving the culture methods and detection technology, and applying genome mining technology were reviewed. The application of these effective methods made the screening of bioactive substances f^om marine Actinomycetes had a broad prospect of development and application.
作者
张晓婷
赫卫清
ZHANG Xiaoting;HE Weiqing(NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences,Beijing 100050, China)
出处
《中国酿造》
CAS
北大核心
2019年第2期21-25,共5页
China Brewing
基金
医科院创新工程项目(2017-I2M-1-012)
关键词
海洋微生物
特殊生境
放线菌
次级代谢产物
marine microorganisms
special habitats
Actinomycetes
secondary metabolite
