摘要
目的研究术前CEA、CA153水平在早期可手术乳腺癌患者中预测预后的价值。方法选取2008年1月～2017年1月在泰安市肿瘤防治院进行乳腺癌根治术的患者共232例。利用生存曲线分析术前CEA、CA153水平与无病生存期(DFS)的关系,同时,对术前CEA与CA153水平、年龄、肿块大小、淋巴结转移数目、ER、PR、HER-2状态进行COX单因素与多因素分析。结果术前血清标志物CEA、CA153水平、肿块大小、淋巴结转移数目、PR、HER-2状态为独立的预后因素,而ER虽然在单因素分析中与DFS相关,但是并非独立的预后因素。年龄与DFS不相关。结论术前CEA、CA153水平是早期可手术乳腺癌患者的独立预后因素,术前标志物CEA、CA153水平较高者DFS相对较短。
Objective To study the value of preoperative CEA and CA153 levels in predicting prognosis in patients with early operable breast cancer.Methods A total of 232 patients who underwent radical mastectomy in Tai'an Tumor Prevention and Treatment Hospital from January 2008 to January 2017 were enrolled.Survival curve was used to analyze the relationship between preoperative CEA,CA153 levels and disease-free survival(DFS).The preoperative CEA,CA153 levels,age,mass size,lymph node metastasis,ER,PR and HER-2 status were performed by COX single factor and multi-factor analysis.Results Preoperative serum marker CEA,CA153 levels,mass size,number of lymph node metastases,PR,and HER-2 status were independent prognostic factors.Whereas ER was associated with DFS in univariate analysis,it was not an independent prognostic factor.Age was not related to DFS.Conclusion Preoperative CEA and CA153 levels are independent prognostic factors for patients with early operable breast cancer.DFS is relatively shorter in patients with higher preoperative markers of CEA,CA153.
作者
何秀玉
冯增鹏
李杰
HE Xiuyu;FENG Zengpeng;LI Jie(Cancer Center,Tai'an Tumor Prevention and Treatment Hospital in Shandong Province,Tai'an 271000,China)
出处
《中国现代医生》
2019年第2期1-4,共4页
China Modern Doctor
