摘要
目的观察针灸联合祖师麻治疗对膝骨关节炎患者血清血管内皮生长因子(vascular endothelialgrowth factor, VEGF)、碱性成纤维细胞生长因子(basic fibroblast growth factor, bFGF)表达的影响。方法选取236例膝骨关节炎患者,采用随机数字表法分为两组,每组118例。对照组予以塞来昔布治疗,观察组给予针灸联合祖师麻治疗。比较两组患者疗效及治疗前后VAS评分、WOMAC评分和血清VEGF、b FGF水平;比较两组患者不良反应的发生率。结果对照组和观察组总有效率分别为87.3%、94.9%,观察组总有效率显著高于对照组(P<0.05);两组治疗前VAS评分、WOMAC评分比较差异无统计学意义(P>0.05),两组治疗后VAS评分、WOMAC评分均显著下降(P<0.05);两组治疗后VAS评分比较差异无统计学意义(P>0.05),而观察组WOMAC评分显著低于对照组(P<0.05);两组治疗前VEGF、bFGF比较差异无统计学意义(P>0.05),两组治疗后VEGF、bFGF均下降(P<0.05),且观察组显著低于对照组(P<0.05);对照组不良反应发生率为3.4%,观察组不良反应发生率为1.7%,两组比较差异无统计学意义(P>0.05)。结论针灸联合祖师麻治疗膝骨关节炎可以减轻炎症反应,抑制滑膜血管新生,有效改善疼痛和关节功能。
Objective To investigate the effect of acupuncture and moxibustion plus Zushima on serum vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)in patients with knee osteoarthritis.Method Two hundred and thirty-six patients with knee osteoarthritis were allocated,using a random number table,to two groups,118 cases each.The control group was treated with Celecoxib and the observation group,with acupuncture and moxibustion plus Zushima.The therapeutic effects,and pre-treatment and post-treatment VAS scores and WOMAC scores and serum VEGF and bFGF levels were compared between the two groups of patients.The adverse reaction incidences were compared between the two groups of patients.Result The total efficacy rate was 87.3%in the control group and 94.9%in the observation group and was significantly higher in the observation group than in the control group(P<0.05).There were no statistically significant pre-treatment differences in the VAS score and WOMAC score between the two groups(P >0.05).The VAS score and WOMAC score decreased significantly in both groups after treatment(P<0.05).After treatment,there was no statistically significant difference in the VAS score between the two groups(P >0.05)but the WOMAC score was significantly lower in the observation group than in the control group(P<0.05).There were no statistically significant pre-treatment differences in VEGF and bFGF between the two groups(P >0.05).After treatment,VEGF and bFGF decreased significantly in both groups(P<0.05)and were significantly lower in the observation group than in the control group(P<0.05).The adverse reaction incidence was 3.4%in the control group and 1.7%in the observation group with no statistically significant difference between the two groups(P >0.05).Conclusion Acupuncture and moxibustion plus Zushima can reduce inflammatory reactions,inhibit synovial angiogenesis,and effectively relive the pain,and improve articular functions in the treatment of knee osteoarthritis.
作者
马文
任小娟
MA Wen;REN Xiao-juan(Urumqi Hospital of Traditional Chinese Medicine,Urumqi 830000,China)
出处
《上海针灸杂志》
2019年第2期224-228,共5页
Shanghai Journal of Acupuncture and Moxibustion
基金
新疆乌鲁木齐市医学会项目(2013ZRQN09)
关键词
针灸疗法
温针疗法
针药并用
骨关节炎
膝
祖师麻
血管内皮生长因子
碱性成纤维细胞生长因子
视觉模拟评分
WOMAC评分
Acupuncture-moxibustion therapy
Warm needling therapy
Acupuncture medication combined
Osteoarthritis,Knee
Zushima
Vascular endothelial growth factor
Basic fibroblast growth factor
VAS score
WOMAC score
