摘要
目的探讨抑郁对不同运动亚型帕金森病(PD)患者生活质量的影响。方法选择原发性PD患者200例(PD组),健康体检者150例(对照组)。PD组又根据主要临床特点分为震颤型组137例和非震颤型组63例。采用汉密尔顿抑郁量表(HAMD-24)对PD组和对照组进行抑郁评分,采用统一PD评定量表(UPDRS)及PD生活质量量表(PDQ-39)分别评价PD组的严重程度和生活质量。结果PD组抑郁发生率明显高于对照组(68.0%vs8.7%,P<0.01)。震颤型组抑郁发生率明显低于非震颤型组(63.5%vs 77.8%,P<0.05)。Pearson相关分析显示,非震颤型组HAMD-24评分与病程、UPDRSⅡ、UPDRSⅢ、汉密尔顿焦虑量表(HAMA-14)和PDQ-39评分总分及各分项中的情感状态、羞耻感、社会支持、交往联络呈正相关,与发病年龄、PDQ-39评分各分项中的认知和睡眠呈负相关。多元logistic回归分析显示,影响PDQ-39总分的影响因素系数从大到小为UPDRSⅢ、H-Y分级、病程、UPDRSⅡ、HAMD-24、发病年龄及HAMA-14(P<0.05)。结论非震颤型患者抑郁发生率较震颤型高,症状严重,且影响非震颤型患者生活质量。
Objective To study the effect of depression on quality of life in patients with different motor subtypes of PD.Methods Two hundred primary PD patients served as a PD group and 150 subjects served as a control group.The PD group were further divided into tremor group(n=137)and tremor-free group(n=63).The depression in PD group and control group was scored according to the HAMD-24.The severity of depression and quality of life in PD group were assessed according to the UPDRS and PDQ-39 respectively.Results The incidence of depression was significantly higher in PD group than in control group(P<0.01)and was significantly lower in tremor group than in tremor-free group(P<0.05).Pearson correlation analysis showed that the HAMD-24 score was positively related with the disease duration,total UPDRSⅡ,UPDRSⅢ,HAMA-14 and PDQ-39 scores and negatively related with the emotion status,sense of shame,social support,contact with others,onset age of disease,cognition of PDQ-39 scores and sleep.Multivariate logistic regression analysis revealed that UPDRSⅢscore,H-Y stage,disease duration,UPDRSⅡand HAMD-24 score,onset age of disease and HAMA-14 score were the factors influencing the total PDQ-39 score in PD patients(P<0.05).Conclusion The incidence of depression is higher and the symptoms of depression are severer in tremor-free patients than in tremor patients and can influence the quality of life in tremor-free patients.
作者
孙政
杜小静
马建军
李学
杨红旗
祁亚伟
吴少璞
李东升
Sun Zheng;Du Xiaojing;Ma Jianjun;Li Xue;Yang Hongqi;Qi Yawei;Wu Shaopu;Li Dongsheng(Zhengzhou University People's Hospital,450003;Deparment of Neurology,Henan Provincial People's Hospital)
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2019年第2期129-132,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
河南省科技发展计划(142300410054)
河南省医学科技攻关计划(201701018)
关键词
抑郁
帕金森病
震颤
生活质量
认知障碍
depression
Parkinson disease
tremor
quality of life
cognition disorders
