摘要
研究改良小柴胡汤剂对乙型肝炎临床疗效及血清肝功能相关指标的影响,为临床的推广应用提供参考。选取2015年1月—2017年12月中国石化集团胜利石油管理局胜利医院收治的乙型肝炎患者114例作为研究对象,根据随机数字表法分为观察组和参照组,每组72例;参照组应用常规治疗方法对患者进行治疗;观察组在参照组的基础上应用改良小柴胡汤剂予以治疗,对比2组治疗后的临床疗效与血清肝功能相关指标。结果显示:(1)观察组的总有效率为98.6%,而参照组的总有效率为87.5%,观察组总有效率明显高于参照组,且差异具有统计学意义(P<0.05)。(2)从治疗后的3个月开始2组研究对象的谷草转氨酶、谷丙转氨酶及总胆红素值均有明显下降,且观察组的各指标值的恢复情况明显高于参照组,差异均具有统计学意义(P<0.05);同时对2组的病毒学指标HBV-DNA与HBeAg进行了比较,观察组的2项指标转阴患者的例数明显高于参照组,差异显著(P<0.05)。(3)2组治疗前的各项肝纤维化指标均无统计学意义(P>0.05);治疗后,2组的层粘连蛋白(LN)、透明质酸酶(HA)、Ⅲ型前胶原(PCⅢ)及Ⅳ型胶原(ⅣC)4项指标明显较治疗前显著(aP<0.05),且观察组的各项指标均明显优于参照组,差异均具有统计学意义(b P<0.05);(4)参照组治疗前后的CD+4、CD+8与NK免疫功能指标无统计学意义(P>0.05);观察组治疗后CD+4与NK的值明显的升高了(P<0.05),CD+8值明显降低(aP<0.05);且明显的优于参照组(b P<0.05)。(5)参照组发生不良反应9例,不良反应发生率12.5%;观察组发生不良反应4例,不良反应发生率为5.5%;观察组不良反应发生率明显高于参照组,且差异显著(P<0.05)。改良小柴胡汤剂应用于乙型肝炎的治疗中提高了临床疗效,改善了血清肝功能相关指标和肝纤维化情况,提高了免疫功能,降低了不良反应发生率,最终提高了患者的生活质量,适合临床的推广�
The research on influence on clinical efficacy of Hepatitis B and related indicator of serum liver function by improved common goldenrop decoction provides the reference for the clinical popularization and application.Method 114 Hepatitis B patients received and cured by our hospital from Jan.2015 to Dec.2017 are selected as the research objects and are divided into the observation group and the reference group based on a random number table,with 72 cases in each group;The reference group treats the patients in the conventional treatment method;The observation group treats the patients by applying the improved common goldenrop decoction on the basis of reference group by comparing two groups of clinical efficacies after treatment and the related indicator of serum liver function.Result(1)The total effective rate of observation group reaches 98.6%,while the total effective rate of reference group reaches 87.5%,so the former is obviously higher than the latter,and their differences are statistically significant(P<0.05);(2)The values of AST,ALT and TBIL of two groups of research objects 3 months after treatment obviously descend,and the recovery condition of various indicators in observation group is obviously higher than that in the reference group.Their differences are statistically significant(P<0.05);In the meantime,the HBV-DNA and HBeAg,two groups of virology indicators,are compared,and the number of patients with two groups of indictors transferring into the negative in observation group are obviously higher than that in reference group,with significant difference(P<0.05);(3)Various liver cirrhosis indicators before two groups of treatment are not statistically significant(P >0.05);After treatment,the indicators of two groups of laminin(LN),hyaluronidase(HA),HF-Ⅲprocollagen(PCⅢ)and IV collagen(ⅣC)are obviously significant than the indicators before treatment(a P<0.05),and various indicators of observation group are obviously better than these of reference group.The difference is statistically significant
作者
燕奎华
崔和春
刘卉
Yan Kuihua;Cui Hechun;Liu Hui(Department of Infectious Diseases,Shengli Hospital,Shengli Petroleum Administration Bureau of China Petrochemical Group,Dongying 257055,China)
出处
《甘肃科学学报》
2019年第1期67-72,共6页
Journal of Gansu Sciences
关键词
改良小柴胡汤剂
常规治疗方法
乙型肝炎
临床疗效
血清肝功能相关指标
Improved common goldenrop decoction
Conventional treatment method
Hepatitis B
Clinical efficacy
Related indicator of serum liver function
