摘要
目的 探究丁苯酞氯化钠注射液联合阿替普酶(rt-PA)静脉溶栓治疗急性缺血性脑卒中(AIS)患者的短期临床效果。方法 选取2016年3月至2018年7月本院收治的94例AIS患者,采用随机数字表法分为两组,各47例。两组均予以补液、吸氧、抗血小板聚集等常规治疗,对照组患者予以rt-PA静脉溶栓治疗,观察组患者予以丁苯酞氯化钠注射液+rt-PA静脉溶栓治疗,两组均治疗14 d。对比两组临床疗效、不良反应发生率、治疗前后脑梗死体积、血清超敏-C反应蛋白(hs-CRP)、S100β蛋白(S100β)、神经特异性烯醇化酶(NSE)水平、神经功能缺损(NIHSS)评分。结果 观察组患者治疗总有效率为93.62%(44/47),较对照组的78.72%(37/47)高(P<0.05);治疗后两组脑梗死体积较治疗前小,观察组脑梗死体积较对照组小(P<0.05);治疗后观察组血清hs-CRP、S100β、NSE水平均较对照组低(均P<0.05);治疗后,两组NIHSS评分均低于治疗前,观察组NIHSS评分低于对照组(P<0.05);两组牙龈出血、头昏、皮疹、脑出血发生率对比,差异均无统计学意义(均P >0.05)。结论 丁苯酞氯化钠注射液联合rt-PA静脉溶栓治疗AIS患者,疗效显著,可缩小脑梗死体积,降低血清hs-CRP、S100β、NSE水平,减轻炎症反应,促进患者神经功能恢复,且不会明显增加不良反应,可为临床AIS治疗提供指导。
Objective To investigate the short-term clinical effect of butylphthalide sodium chloride injection combined with intravenous thrombolysis and ateprase(rt-PA)in the treatment of acute ischemic stroke(AIS).Methods 94 patients with AIS treated at our hospital from March,2016 to July,2018 were selected and randomly divided into a control group and an observation group,47 cases for each group.Both groups were given routine treatment,such as fluid infusion,oxygen inhalation,and anti-platelet aggregation.The control group were given rt-PA intravenous thrombolysis.The observation group were given butylphthalide sodium chloride injection and rt-PA intravenous thrombolysis.Both groups were treated for 14 days.The Clinical efficacies,incidences of adverse reactions,cerebral infarction volumes before and after treatment,and serum levels of hypersensitive-Creactive protein(hs-CRP),S100βprotein(S100β),and neuron-specific enolase(NSE)as well as neurological deficit(NIHSS)score were compared between the two groups.Results The total effective rate was higher in the observation group than in the control group[93.62%(44/47)vs.78.72%(37/47),P<0.05].After the treatment,the cerebral infarction volume decreased in both groups,and was lower in the observation group than in the control group(P<0.05).After the treatment,the serum levels of hs-CRP,S100β,and NSE were lower in the observation group than in the control group(all P<0.05).After the treatment,the NIHSS score decreased in both groups,and was lower in the observation group than in the control group(P<0.05).There were no statistical differences in the incidences of gingival bleeding,dizziness,rash,and cerebral hemorrhage between the two groups(all P >0.05).Conclusions Butylphthalide sodium chloride injection combined with rt-PA intravenous thrombolysis in the treatment of AIS patients is effective,can reduce the cerebral infarction volume and the serum levels of hs-CRP,S100beta,and NSE,alleviate inflammation,and promote the recovery of neurological function,and does not signifi
作者
刘晓锐
Liu Xiaorui(Department of Neurology,Xiangyanfg County People's Hospital,Xuchang 461700,China)
出处
《国际医药卫生导报》
2019年第3期404-408,共5页
International Medicine and Health Guidance News
关键词
急性缺血性脑卒中
丁苯酞氯化钠注射液
阿替普酶
溶栓
神经功能
Acute ischemic stroke
Butylphthalide sodium chloride injection
Alteplase
Thrombolysis
Neurological function
