摘要
目的 探讨腹泻患儿采用酪酸梭菌联合锌制剂治疗的效果及对炎症因子的影响。方法 选取2016年3月至2018年3月在本院就诊的小儿腹泻患者78例,参照随机数表法分为对照组(n=39)和观察组(n=39)。对照组采用锌制剂治疗,观察组予酪酸梭菌联合锌制剂治疗,对比两组炎症因子水平、症状改善时间及疗效。结果 观察组治疗后超敏-C反应蛋白(hs-CRP)、白细胞介素8(IL-8)、IL-6水平[(2.78±1.64)mg/L、(82.23±6.41)ng/L、(143.92±9.72)ng/L]均低于对照组[(4.13±1.86)mg/L、(101.67±9.18)ng/L、(192.56±9.65)ng/L],治疗总有效率(97.44%)高于对照组(76.92%),差异有统计学意义(P<0.05);观察组症状(腹痛、呕吐、体温)改善时间及便检正常时间[(1.14±0.32)d、(1.34±0.32)d、(3.24±0.56)d、(5.06±0.52)d]均较对照组短[(2.34±0.41)d、(2.73±0.42)d、(6.72±1.14)d、(9.35±0.92)d],差异有统计学意义(P<0.05)。结论 酪酸梭菌联合锌制剂治疗可有效降低腹泻患儿炎症因子水平,改善临床症状,提高治疗效果。
Objective To investigate the therapeutic effect of clostridium butyricum combined with zinc preparation on pediatric diarrhea and its effect on inflammatory factors.Methods Seventy-eight children with diarrhea from March 2016 to March 2018 were randomly divided into two groups:control group(n=39)and observation group(n=39).The control group was treated with zinc preparation,and the observation group was treated with clostridium butyricum combined with zinc preparation.And the inflammatory factor level,symptom improvement time,and curative effect were compared between the two groups.Results After treatment,the levels of hs-CRP,IL-8,and IL-6 in the observation group[(2.78±1.64)mg/L,(82.23±6.41)ng/L,(143.92±9.72)ng/L]were significantly lower than those in the control group[(4.13±1.86)mg/L,(101.67±9.18)ng/L,(192.56±9.65)ng/L],the total effective rate(97.44%)was significantly higher than that in the control group(76.92%);the improvement time of symptoms(abdominal pain,vomiting,body temperature)and the time of stool examination returning to normal in the observation group[(1.14±0.32)d,(1.34±0.32)d,(3.24±0.56)d,(5.06±0.52)d]were significantly shorter than those in the control group[(2.34±0.41)d,(2.73±0.42)d,(6.72±1.14)d,(9.35±0.92)d](P<0.05).Conclusion The treatment of clostridium butyricum combined with zinc preparation can effectively reduce the level of inflammatory factors in children with diarrhea,improve clinical symptoms and the therapeutic effect.
作者
刘保华
Liu Baohua(Department of Pediatrics,Tanghe County People's Hospital,Henan 473400,China)
出处
《国际医药卫生导报》
2018年第23期3657-3660,共4页
International Medicine and Health Guidance News
关键词
小儿腹泻
酪酸梭菌
锌制剂
炎症因子
症状改善
Pediatric diarrhea
Clostridium butyricum
Zinc preparation
inflammatory factors
Symptom improvement
