摘要
目的探讨血清胱抑素C及尿N-乙酰-β-D-葡萄糖苷酶联合检测在狼疮性肾炎诊断中的应用效果。方法将我院2014年1月至2018年6月收治的100例系统性红斑狼疮患者设为研究组,并根据研究组患者肾损伤状况分为单纯狼疮组(n=24)、早期肾炎组(n=36)、临床肾炎组(n=40),选择同期体检的100名健康人员设为健康组,检测受检者血清胱抑素C和尿N-乙酰-β-D-葡萄糖苷酶水平,并比较不同受检者检测结果的差异。结果研究组血清胱抑素C、尿N-乙酰-β-D-葡萄糖苷酶水平明显高于健康组,差异具有统计学意义(P<0.05)。临床肾炎组、早期肾炎组、单纯狼疮组患者血清胱抑素C、尿N-乙酰-β-D-葡萄糖苷酶水平及阳性率比较,差异均具有统计学意义(P<0.05)。联合诊断对早期狼疮性肾炎的诊断灵敏度、准确度均高于血清胱抑素C、尿N-乙酰-β-D-葡萄糖苷酶单独检测,差异具有统计学意义(P<0.05)。结论血清胱抑素C及尿N-乙酰-β-D-葡萄糖苷酶联合检测应用于狼疮性肾炎诊断中可提升早期诊断效果。
Objective To investigate the application effect of combined detection of serum cystatin C and urinary Nacetyl-beta-D-glucosidase in the diagnosis of lupus nephritis. Methods One hundred patients with systemic lupus erythematosus in our hospital from January 2014 to June 2018 were selected as study group and divided into simple lupus group(n=24), early nephritis group(n=36) and clinical nephritis group(n=40) according to the status of renal injury, while100 healthy persons who had undergraduate physical examination in the same period were selected as healthy group. The levels of serum cystatin C and urinary N-acetyl-β-D-glucosidase of different objects were measured and the differences of the results between different objects were compared. Results The levels of serum cystatin C and urinary N-acetyl-β-Dglucosidase in the study group were significantly higher than those in the healthy group, the differences were statistically significant(P <0.05). There were significant differences in the levels of serum cystatin C and urinary N-acetyl-β-D-glucosidase, positive rate among the patients of the clinical nephritis gruop, early nephritis group and simple lupus group(P <0.05). The sensitivity and accuracy of combined diagnosis for early lupus nephritis were higher than those of serum cystatin C and urine N-acetyl-beta-D-glucosidase respectively, the differences were statistically significant(P <0.05).Conclusion The combined detection of serum cystatin C and urinary N-acetyl-beta-D-glucosidase can improve the early diagnosis of lupus nephritis.
作者
郭格丽
梁周侠
张锁平
杨亚莉
GUO Ge-li;LIANG Zhou-xia;ZHANG Suo-ping;YANG Ya-li(the People's Hospital of Fufeng County,Baoji 722200,China)
出处
《临床医学研究与实践》
2019年第3期111-113,共3页
Clinical Research and Practice
