摘要
研究了一套新的从冬凌草中提取冬凌草甲素及处理提取液的方法。采用溶剂套用的方式提取冬凌草甲素,得到目标产物浓度较高的提取液。应用单因素变量法找出了冬凌草甲素浸取的适宜条件:物料溶剂比为1(g)∶8(ml),新旧溶剂套用组成的混合溶剂中冬凌草甲素的含量为652 mg/L,温度为35℃,p H5.5。通过往提取液中逐次添加水改变提取液的极性,并且配以低温,得到一系列浓度不同的冬凌草甲素沉析物。沉析处理后余下的提取液通过减压蒸发,得到质量分数为22.2%的冬凌草甲素浸膏,显著高于文献报道数据。在整个提取液处理过程中,几乎没有冬凌草甲素的损失,解决了常规的脱溶浓缩过程中冬凌草甲素大量损失的问题。
A new method for extracting oridonin from rubescens and processing extracts was studied.The solvent back-mixing method was used to extract oridonin,and the extract with higher target product concentration was obtained.The optimum conditions for the extraction of oridonin were found by the single factor method:the ratio of material to solvent was 1(g):8(ml);the oridonin content contained in mixed solvent was 652mg/L;temperature was 35℃;pH was 5.5.By adding water to change the polarity of the extracted solvent,and accompanied by low-temperature fractional precipitation.The remaining extracted solvent was evaporated under reduced pressure to obtain an extractum of 22.2% of oridonin,which was significantly higher than that reported in the literature.After pretreatment,the extracted had almost no loss of oridonin during the desolvation process,which solved the problem of large loss of oridonin in the conventional concentration process.
作者
李昌辉
孟玲
桂霞
云志
LI Changhui;MENG Ling;GUI Xia;YUN Zhi(College of Chemical Engineering,Nanjing Tech University,Nanjing 210009,Jiangsu,China)
出处
《化工学报》
EI
CAS
CSCD
北大核心
2018年第A02期240-245,共6页
CIESC Journal
基金
江苏省高校优势学科建设工程资助项目
国家科技支撑计划项目(2015BAD15B07)
国家自然科学基金项目(21676145)~~
关键词
冬凌草甲素
分离
溶剂套用
浸取
脱溶
乙醇
oridonin
separation
mixture of used solvent and new solvent
leaching
desolvental
ethanol
