摘要
目的探讨分析维持性血液透析患者血尿酸与动脉钙化的相关性。方法选择在该院维持性血液透析患者117例,检测患者血尿酸以及相关临床指标,并采用多层螺旋CT测定患者冠状动脉钙化积分(CACs),比较分析高尿酸血症组与血尿酸正常组患者各临床指标与冠状动脉钙化积分相关性。结果 117例维持性血液透析患者,其中血尿酸升高患者68例,高尿酸血症发生率为58.12%;高尿酸血症组患者DBP、SBP、三酰甘油(TG)、总胆固醇(TC)、高敏C反应蛋白(hs-CRP)以及CACs均较血尿酸正常组显著升高,差异具有统计学意义(P<0.05);经相关性分析,血尿酸水平与患者TG、hs-CRP以及CACs呈显著正相关关系(P<0.05);影响持续性血液透析患者重度血管钙化(CACs>400)发生的危险因素包括患者hs-CRP水平、血尿酸水平以及高血压。结论持续性血液透析患者中高尿酸血症发生率较高,患者血尿酸水平与冠状动脉钙化之间具有着密切联系,且高血尿酸水平是引发患者冠状动脉钙化的重要因素,因此对于维持性血液透析患者心脑血管并发症的预防需重视对高尿酸血症的治疗。
Objective To investigate the correlation between serum uric acid and arterial calcification in maintenance hemodialysis patients.Methods 117 patients with maintenance hemodialysis were selected in our hospital.The blood uric acid and related clinical indexes were detected and the coronary artery calcification score(CACs)was measured by multislice spiral CT.The correlation between clinical indicators and coronary artery calcification score in hyperuricemia group and normal group was analyzed.Results The 117 patients with maintenance hemodialysis,68 patients had elevated serum uric acid,and the incidence of hyperuricemia was 58.12%.The levels of DBP,SBP,TG,TC,hs-CRP and CACs in the hyperuricemia group were significantly higher than those in the normal group(P<0.05).By correlation analysis,serum uric acid levels were positively correlated with TG,hs-CRP and CACs in patients(P<0.05).The risk factors for severe vascular calcification(CACs>400)in patients with persistent hemodialysis include hs-CRP levels,serum uric acid levels,and hypertension.Conclusion The incidence of hyperuricemia is high in continuous hemodialysis patients.There is a close relationship between serum uric acid level and coronary artery calcification.And the level of high blood uric acid is an important factor causing coronary artery calcification in patients.Therefore,the prevention of cardiovascular and cerebrovascular complications in maintenance hemodialysis patients should be paid more attention to the treatment of hyperuricemia.
作者
杨军
缪洪芸
YANG Jun;MIAO Hongyun(Department of Nephrology,Jiangjin Central Hospital of Chongqing,Chongqing 402260,China)
出处
《国际检验医学杂志》
CAS
2019年第3期318-320,324,共4页
International Journal of Laboratory Medicine
基金
重庆市教委基金项目(KJ080313)
关键词
维持性血液透析
血尿酸
动脉钙化
相关性分析
maintenance hemodialysis
blood uric acid
arterial calcification
correlation analysis
