摘要
肺炎克雷伯菌是医院内感染最常见的细菌之一,也是血流感染和泌尿道感染的第二大致病菌。近年来,肺炎克雷伯菌耐药菌株的出现已成为抗感染界关注的焦点。目前,耐药肺炎克雷伯菌的治疗主要是联合用药,但联合用药存在不良反应大、成本高、更易产生耐药性等问题。随着中医中药的治疗作用被逐渐重视,中药作为替代疗法或中西药结合抗感染已进入研究者的视线,因此,用以评价药物疗效的动物模型引起广泛关注。该文就肺炎克雷伯菌动物感染模型及在中药抗感染应用中的研究进展作以下综述。
Klebsiella pneumoniae is one of the most common bacteria in nosocomial infections,and the second pathogen in bloodstream infections and urinary tract infections.In recent years,the emergence of Carbapenem-Resistant Klebsiella Pneumonia has become the focus in the field of anti-infection.At present,the treatment of Carbapenem-Resistant Klebsiella Pneumonia is mainly combined drug use,but which exists possible drawbacks including many side effects,higher cost,and more serious drug resistance and so on.With the increasing attention of the therapeutic effect,Chinese traditional medicine begins to come into researchers′sight as an alternative therapy or combination of traditional Chinese and Western medicine.Therefore,animal models used to evaluate the efficacy of drugs have been attracted wide attention.This article reviews animal models of Klebsiella Pneumonia infection and their applications in anti-infection of Chinese traditional medicine.
作者
赵娟
刘志远
刘贵建
ZHAO Juan;LIU Zhiyuan;LIU Guijian(Department of Clinical Laboratory,Guang′anmen Hospital China Academy of Chinese Medical Sciences,Beijing 100053,China)
出处
《国际检验医学杂志》
CAS
2019年第3期269-272,276,共5页
International Journal of Laboratory Medicine
关键词
肺炎克雷伯菌
动物模型
感染
中草药
Klebsiella Pneumonia
animal models
infection
Chinese traditional medicine
