摘要
炎症性肠病(inflammatory bowel disease, IBD)是由免疫、遗传、环境三因素共同作用导致,由于它存在发病早期症状不典型及后期病变多样化的特点,因此在发病早期准确诊断IBD是一个难点,目前诊断依赖于内镜检查和影像学检查,但是患者缺乏依从性.肠道菌群在IBD中的特征性变化提示它可能成为一种新的生物标记物.近年来多项临床研究深入探讨肠道菌群在IBD鉴别诊断、疾病活动度、肠外表现等中的特征性变化,并建立肠道菌群诊断模型,获得了较高的敏感性和特异性,但由于该模型易受外界因素干扰,仍需进一步完善.本文拟将综述肠道菌群对IBD的诊断价值及临床意义.
Inflammatory bowel disease(IBD)is caused by immune,genetic,and environmental factors together.It is difficult to accurately diagnose IBD early because it is characterized by atypical symptoms at early stage and diverse lesions at late stage.The diagnosis is currently dependent on endoscopic and imaging examinations,but patients often have poor compliance.The characteristic change of gut microbiota in IBD suggests that it may become a new biomarker.In recent years,a number of clinical studies have focused on the role of characteristic changes of gut microbiota in the differential diagnosis,disease activity,and extra-intestinal manifestations of IBD.These studies have established a gut microbiota based diagnostic model with high sensitivity and specificity,but the model is susceptible to be influenced by external factors and needs to be further improved.This paper reviews the diagnostic value and clinical significance of gut microbiota in IBD.
作者
曹莞婷
范一宏
吕宾
Wan-Ting Cao;Yi -Hong Fan;Bin Lv(Department of Gastroenterology,the First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310006,Zhejiang Province,China)
出处
《世界华人消化杂志》
CAS
2019年第3期190-196,共7页
World Chinese Journal of Digestology
基金
国家自然基金资助项目
No.81473506
浙江省自然科学基金资助项目
No.LY17H29009
浙江省中医药科技计划项目
Nos.2016ZB047
2017ZA056~~
关键词
炎症性肠病
肠道菌群
鉴别诊断
疾病严重程度
肠外表现
Inflammatory bowel disease
Gut microbiota
Differential diagnosis
Disease activity
Extra-intestinal manifestations
