摘要
目的探讨血清脂蛋白相关磷脂酶A2(Lp-PLA2)水平、平均血小板体积(MPV)、血小板分布宽度(PDW)与围绝经期女性冠心病的关系。方法选取2015年1月—2018年1月因"胸闷、气促、潮热"而就诊于沧州市人民医院及沧州市妇幼保健院的围绝经期女性127例,根据冠状动脉造影结果分为冠心病组53例和非冠心病组74例。比较两组患者一般资料[包括年龄、吸烟史、高血压病史、糖尿病病史、腹型肥胖情况、久坐情况]、血脂指标[包括总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、血清Lp-PLA2水平、MPV、PDW,血清Lp-PLA2水平、MPV、PDW与围绝经期女性冠心病的关系分析采用多因素Logistic回归分析。结果两组患者年龄、吸烟史、高血压病史、糖尿病病史、腹型肥胖者所占比例、久坐者所占比例、TG、HDL-C比较,差异无统计学意义(P>0.05);冠心病组患者TC、LDL-C及血清Lp-PLA2水平高于非冠心病组,MPV、PDW大于非冠心病组(P<0.05)。多因素Logistic回归分析结果显示,血清Lp-PLA2水平[OR=1.662,95%CI(1.154,2.393)]、MPV[OR=2.575,95%CI(1.439,4.610)]、PDW[OR=1.540,95%CI(1.045,2.271)]是围绝经期女性冠心病的影响因素(P<0.05)。结论血清Lp-PLA2水平、MPV、PDW是围绝经期女性冠心病的影响因素。
Objective To investigate the relationship between serum Lp-PLA2 level,MPV,PDW and coronary heart disease in perimenopausal women.Methods A total of 127 perimenopausal women with chest congestion,shortness of breath and hectic fever admitted to the People's Hospital of Cangzhou and Cangzhou Women and Children's Health Institute from January 2015 to January 2018 were selected,and they were divided into coronary heart disease group(n=53)and non-coronary heart disease group(n=74)according to the results of coronary angiography.General information(including age,smoking history,history of hypertension and diabetes,incidence of abdominal obesity,sedentary status),blood lipid index(including TC,TG,LDL-C and HDL-C),serum Lp-PLA2 level,MPV and PDW were compared between the two groups;multivariate Logistic regression was used to analyze the relationship between serum Lp-PLA2 level,MPV,PDW and coronary heart disease in perimenopausal women.Results There was no statistically significant differences in age,proportion of patients with smoking history,hypertension history,diabetes history,proportion of patients with abdominal obesity,proportion of patients with sedentary status,TG or HDL-C between the two groups(P>0.05).TC,LDL-C,serum Lp-PLA2 level,MPV and PDW in coronary heart disease group were statistically significantly higher than those in non-coronary heart disease group(P<0.05).Multivariate Logistic regression analysis showed that,serum Lp-PLA2 level〔OR=1.662,95%CI(1.154,2.393)〕、MPV〔OR=2.575,95%CI(1.439,4.610)〕、PDW〔OR=1.540,95%CI(1.045,2.271)〕were influencing factors of coronary heart disease in perimenopausal women(P<0.05).Conclusion Serum Lp-PLA2 level,MPV and PDW are influencing factors of coronary heart disease in perimenopausal women.
作者
刘东升
韩海莉
何芬
LIU Dong-sheng;HAN Hai-li;HE Fen(Department of Cardiology,the People's Hospital of Cangzhou,Cangzhou 061001,China;Department of Internal Medicine,Cangzhou Women and Children's Health Institute,Cangzhou 061001,China)
出处
《实用心脑肺血管病杂志》
2018年第12期26-29,34,共5页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
