摘要
目的:观察七味三芎汤对动脉粥样硬化大鼠血清TNF-α、IL-6水平的影响,探讨其治疗AS的作用机制。方法:采用饲喂高脂饲料胃复制大鼠AS模型,以辛伐他汀为对照,观察七味三芎汤喂饲10周后各组大鼠血清TNF-α、IL-6水平。结果:七味三芎汤和辛伐他汀组大鼠血清TNF-α、IL-6水平均低于模型组。结论:七味三芎汤可降低血清TNF-α、IL-6水平,通过抗炎作用达到改善斑块的稳定性。
Objective ： To observe the effect of Qiwei Sanxiong Decoction on serum levels of TNF- α and IL-6 in atherosclerosis （ AS ） rats and the mechanism of action. Methods ： Athero-sclerosis model was established by feeding rats with high fat diet. After 10 weeks of Qiwei Sanxiong Decoction administration, serum levels of TNF- α and IL-6 were examined. Results ： In both of the treatment group and the simvastatin group, the inflammatory factor levels of TNF- α and IL-6 were lower than those in the model group. Conclusion ： Qiwei Sanxiong Decoction could alleviate AS and this may related to its effect on inhibiting the inflammatory response of vascular endothelium. Atherosclerotic plaque was stabilized by Qiwei Sanxiong Decoetiontion.
出处
《辽宁中医药大学学报》
CAS
2012年第2期171-173,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
西安市科技计划项目[SF08001(3)]
