摘要
目的探讨斑蝥酸钠维生素B6注射液在肿瘤患者中应用的疗效及安全性。方法对我院使用斑蝥酸钠维生素B6注射液治疗的960例肿瘤患者进行病例信息收集,采用生物统计学方法分析药物适应症、治疗疗程、用法用量、不良反应等资料。结果斑蝥酸钠维生素B6注射液主要用于晚期肺癌、晚期肝癌患者,用法及用量基本符合药物使用说明书要求;完全符合说明书适应症者754例,符合率为78.54%,不符合说明书适应症者206例,占21.46%;斑蝥酸钠维生素B6注射液治疗肺癌、肝癌的临床总有效率高于乳腺癌、食道癌、结直肠癌、膀胱癌、宫颈癌等其他肿瘤,差异无统计学意义;合并用药<3种者201例,占20.94%,合并用药3～5种者321例,占33.44%,合并用药6～10种者375例,占39.06%,合并用药10种以上者63例,占6.56%;有88例患者出现不良反应,主要有恶心、呕吐、肝功能损伤、肾功能损伤、发热及静脉炎等,但程度较轻,为中度或者轻度,且均经停药及对症处理后消失。结论斑蝥酸钠维生素B6注射液临床应用广泛,大多数患者符合用药说明书所规定用量、疗程及适应症,但仍存在不合理使用情况,应引起临床重视。
Objective To investigate the efficacy and safety of cantharidin and vitamin B6 injection in cancer patients.Methods The form of"drug re-evaluation report management system"was filled for 960 cases of patients treated by using disodium cantharidinate and vitamin B6 injection in our hospital.Medication indications,treatment courses,dosage,adverse reactions and other data were analyzed by using biostatistics method.Results Disodium cantharidinate and vitamin B6 injection was mainly used for patients with advanced lung cancer and advanced liver cancer,and the dosage consistent with drug usage instructions.Among 960 cases of the patients,754 cases completely met the manual indications,with the rate of 78.54%,but 206 cases didn’t,accounting for 21.46%.Total effective rate of sodium hyaluronate and vitamin B6 injection in treatment of lung cancer and liver cancer was higher than that of breast cancer,esophageal cancer,colorectal cancer,bladder cancer,cervical cancer and other tumors,without significant difference.The number of combined medication was less than 3 in 201 cases,accounting for 20.94%,3~5 in 321 cases,accounting for 33.44%,and 6~10 in 375 cases,accounting for 39.06%,and more than 10 in 63 cases,accounting for 6.56%.Adverse reactions occurred in 88 cases of patients,including nausea,vomiting,liver damage,kidney damage,fever and phlebitis,but all were moderate or mild,and disappeared after withdrawal and symptomatic treatment.Conclusion Cantharidin sodium and vitamin B6 injection were widely used in clinical practice,and the majority of patients were in accordance with prescribed dosage,treatment course and disease,but there were still unreasonable use.It should be paid more clinical attention.
作者
李丽静
臧亚茹
梁君伟
于文会
佟艳军
LI Lijing;ZANG Yaru;LIANG Junwei;YU Wenhui(Department of Pharmacy,Affiliated Hospital of Chengde Medical College,Chengde,Hebei,067000,China;Department of Radiotherapy and Chemotherapy,Affiliated Hospital of Chengde Medical College,Chengde,Hebei,067000,China;Medical Record Room,Affiliated Hospital of Chengde Medical College,Chengde,Hebei,067000,China)
出处
《肿瘤药学》
CAS
2018年第5期799-802,807,共5页
Anti-Tumor Pharmacy
基金
河北省科技计划项目(162777263)
