摘要
目的探讨淋巴结瘘型支气管结核患者采用经支气管镜治疗的效果和优势。方法选择2017年3月至2018年3月于我院接受治疗的淋巴结瘘型支气管结核患者64例,采用随机数字表法将其分为实验组与参照组,每组32例。其中参照组采用常规结核病化疗方式,实验组在化疗基础上予以支气管镜下局部注射治疗,对比2组患者治疗期间痰液转阴、病灶吸收、临床效果及不良反应情况。结果实验组治疗1个月(59.38%)、2个月(81.25%)、3个月(93.75%)后患者痰菌转阴比例明显高于参照组(25.00%、34.38%、46.88%),两者差异明显(P<0.05)。治疗后1个月2组患者病灶吸收比例(21.88%、18.75%)无显著差异(P>0.05),实验组治疗2个月(65.63%)、3个月(96.88%)后患者病灶吸收率高于参照组(27.13%、34.38%),组间差异明显(P<0.05)。实验组淋巴结瘘型支气管结核临床治疗总有效率(93.75%)明显优于参照组(59.38%),对比差异明显(P<0.05)。2组患者淋巴结瘘型支气管结核治疗后肝功能异常、白细胞下降、胃肠道异常等不良反应发生率(12.50%、15.63%)未见显著差异(P>0.05)。结论淋巴结瘘型支气管结核患者采用经支气管镜治疗方式能够有效提升化疗临床效果,提高患者痰菌转阴率,促进患者病灶得以较好吸收,且该治疗方式不良反应较少,具有较高的安全性,应予以临床推广。
Objective To study the effects and advantages of the treatment of lymph node fistula type bronchial tuberculosis by bronchoscopy. Methods A total of 64 patients with lymph node fistula bronchial tuberculosis who received treatment in our hospital from March 2017 to March 2018 were selected. The control group was treated with conventional chemotherapy for tuberculosis,and the experimental group was treated with bronchoscopy. Sputum conversion,lesion absorption,clinical effect and adverse reactions were compared between the two groups. Results After 1 month(59.38%),2 months(81.25%) and 3 months(93.75%),the proportion of sputum bacteria becoming to negative in the experimental group was significantly higher than that in the control group(25.00%,34.38%,46.88%,P<0.05). There was no significant differences(P>0.05) in the proportion of lesion absorption(21.88%,18.75%) between the 2 groups at 1 month after treatment(65.63%) and 3 months after treatment(96.88%). The rate of lesion absorption in the experimental group was significantly higher than that in the control group(27.13%,34.38%,P<0.05).The total effective rate of clinical treatment of lymph node fistula bronchial tuberculosis in the experimental group was significantly higher than that of the reference group,with significant difference(93.75%,59.38%,P<0.05). There was no significant difference in the incidence of adverse reactions(12.50%,15.63%) after treatment of lymph node fistula bronchial tuberculosis between the 2 groups(P<0.05). Conclusion The treatment with lymph node fistula type bronchial tuberculosis can effectively improve the clinical effect of chemotherapy,improve the sputum negative rate of the patients,and promote the full absorption of the lesions of the patients. In addition,this treatment has fewer adverse reactions and higher safety,which should be promoted clinically.
作者
叶涛生
张培泽
曾旋
李敏
何俊梅
唐怡敏
张娇红
YE Tao-sheng;ZHANG Pei-ze;ZENG Xuan;LI Min;HE Jun-mei;TANG Yi-min;ZHANG Jiao-hong(The SecondAffiliated Hospital of South University of science and technology,Shenzhen Third People's Hospital,Guangdong Shenzhen 518112,China)
出处
《新发传染病电子杂志》
2018年第4期202-205,共4页
Electronic Journal of Emerging Infectious Diseases
基金
国家自然科学基金面上项目(81671984)
深圳市科技计划项目(JCYJ20160427184123851)
深圳市“医疗卫生三名工程”项目(SZSM201412001)
关键词
支气管镜
淋巴结瘘
支气管结核
治疗效果
Bronchoscope
Lymph node fistula
Bronchial tuberculosis
Treatment effect
