摘要
目的探讨行HAART与未行HAART的HIV合并新型隐球菌脑膜脑炎的MRI表现特点。方法回顾性分析13例艾滋病合并新型隐球菌脑膜脑炎患者的MRI和临床资料。按照并发新型隐球菌脑膜脑炎时是否已行HAART分为2组,分析两组患者脑MRI表现,探讨其各自特点。结果行HAART组4例中出现典型脑膜强化2例(50.00%);脑实质结节性肉芽肿2例(50.00%);脑实质损害灶、缺血灶4例(100.00%)。未行HAART组9例中出现血管周围间隙增宽、胶状假囊7例(77.78%),脑实质损害灶、缺血灶6例(66.67%);结节性肉芽肿1例(11.11%),脑膜强化0例。结论行HAART组MRI表现以典型脑膜强化和脑实质结节性肉芽肿为特点,未行HAART组MRI表现以血管周围间隙增宽及胶状假囊较为典型,病灶主要分布于双侧基底节区。
Objectives To analyze the magnetic resonance imaging(MRI)findings of HIV-associated cryptococcal meningoencephalitis and explore the difference between patients with and without highly active antiretroviral therapy(HARRT).Methods The MRI and clinical data of HIV-associated cryptococcal meningoencephalitis in 13 patients were retrospectively analyzed.The enrolled 13 patients were divided into 2 groups.There were 4 patients in the HARRT-group and 9 patients in the non-HARRT-group.Their cranial MRI characterizations and differences were detected and analyzed between the 2 groups.Results In the HARRT-group(n=4),typical focal meningeal enhancement(n=2,50%),parenchymal granuloma(n=2,50%)and parenchymal focal lesions or/and cerebral ischaemia(n=4,100%)were detected.In the non-HARRT-group(n=9),pseudocysts or/and dilated V-R(Virchow-Robin)spaces(n=7,77.78%),parenchymal lesions or/and cerebral ischaemia(n=6,66.67%)and granulomatous lesions(n=1,11.11%)were detected,while no contrast-enhancement focal meningeal lesions were detected.Conclusions The MRI characteristics of patients with HARRT were the typical focal meningeal enhancement and parenchymal granuloma.However,the specific MRI findings of patients without HAART were pseudocysts and dilated V-R spaces that concentrated in the bilateral basal ganglia.
作者
李航
汪明月
鲁植艳
LI Hang;WANG Ming-yue;LU Zhi-yan(Department of Radiology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China)
出处
《新发传染病电子杂志》
2016年第1期38-41,共4页
Electronic Journal of Emerging Infectious Diseases
基金
湖北省自然基金(2011CDC125)
关键词
艾滋病
新型隐球菌
脑膜脑炎
磁共振成像
高效抗反转录病毒治疗
Human immunodeficiency virus infection
Cryptococcus neoformans
Meningoencephalitis
M agnetic resonance imaging
Highly active antiretroviral therapy
