摘要
目的:探讨对甲状腺功能减退的孕妇进行治疗前后妊娠期高血压疾病的发病情况。方法:选择2013年1月～2014年12月分娩的孕产妇1 567例作为对照组,2015年1月～2017年12月分娩的孕产妇2 080例作为观察组,对照组孕期未检查甲状腺功能,观察组初次产检即检查甲状腺功能,诊断妊娠合并甲状腺功能减退者给予左旋甲状腺素片口服,比较两组孕产妇妊娠期高血压疾病、妊娠期高血压、子痫前期的发生率。结果:观察组总的妊娠期高血压疾病发生率低于对照组,差异有统计学意义(χ2=6. 26,P <0. 05)。观察组妊娠期高血压发生率和对照组差异无统计学意义(χ2=0. 44,P> 0. 05)。观察组子痫前期发生率低于对照组,差异有统计学意义(χ2=13. 20,P <0. 05)。将孕产妇分为非高龄组(<35岁)和高龄组(≥35岁)后,观察组妊娠期高血压疾病发生率低于对照组,差异有统计学意义(P <0. 05)。结论:对妊娠期甲状腺功能减退、亚临床甲状腺功能减退积极干预治疗,可以降低妊娠期高血压疾病的发病率,尤其是子痫前期的发病率,使高血压程度减轻。
Objective To investigate the incidence of hypertensive disorders in pregnancy in pregnant women with hypothyroidism before and after treatment.Method 1 567 pregnant women delivered from January 2013 to December 2014 in Fengtai Integrated Traditional Chinese and Western Medicine Hospital were selected as the control group,2 080 pregnant women delivered from January 2015 to December 2017 as the observation group.The control group did not examine thyroid function during pregnancy.In the observation group,thyroid function was examined at the first prenatal examination,and levothyroxine tablets were given orally to the pregnant women with hypothyroidism.The incidence of hypertensive disorders in pregnancy,gestational hypertension and preeclampsia were compared between the two groups.Results The incidence of hypertensive disorders in pregnancy in the observation group was lower than that in the control group,and the difference was statistically significant(χ^2=6.26,P<0.05).The incidence of gestational hypertension in the observation group was not significantly different from that in the control group(χ^2=0.44,P>0.05).The incidence of pre-eclampsia in the observation group was lower than that in the control group,and the difference was statistically significant(χ^2=13.20,P<0.05).After dividing the pregnant women into the group of less than 35 years old and the group of more than or equal to 35 years old,the incidence of hypertensive disorders in pregnancy in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Active treatment of hypothyroidism and subclinical hypothyroidism during pregnancy can reduce the incidence of hypertensive disorders in pregnancy,especially the incidence of pre-eclampsia,and reduce the degree of hypertension.
作者
阮冀
李占辉
崔萌
RUAN Ji;LI Zhan-hui;CUI Meng(Department of gynaecology and obstetrics,Beijing Fengtai Integrated Traditional Chinese and Western Medicine Hospital,Beijing 100072,China)
出处
《吉林医学》
CAS
2019年第1期57-58,共2页
Jilin Medical Journal
