摘要
目的:探讨甲状腺过氧化物酶抗体(TPOAb)阳性甲状腺功能减退与孕中期子痫前期的关系。方法:选取诊断与排除标准合格且完整的病例88例,其中TPOAb阳性甲状腺功能减退症(甲减)孕妇23例;TPOAb阴性甲状腺功能减退症(甲减)患者65例,另外选择80例正常孕妇作为对照组,回顾性分析患者的甲状腺激素水平以及肝肾功能检验指标,并统计患者孕中期子痫前期临床症状人数,对结果进行分析。结果:TPOAb阳性甲减组、TPOAb阴性甲减组与对照组比较,FT_3、FT_4水平明显降低;TSH、TPOAb及收缩压、舒张压水平明显升高,差异有统计学意义(P<0.05);TPOAb阳性甲减组与TPOAb阴性甲减组、对照组比较收缩压、舒张压水平、ALT、AST、CRE、BUN、CYSC、GLU水平明显升高,差异有统计学意义(P<0.05);TPOAb阳性甲减组与TPOAb阴性甲减组、对照组比较,蛋白尿、高血压、水肿、尿糖(+)、肝酶异常、血小板降低等子痫前期临床症状患病率增加。结论:TPOAb阳性甲减孕妇孕中期更容易罹患子痫前期症状,应及时并定期监测甲状腺功能、调整药物剂量,改善其甲状腺功能,以降低重度子痫前期的发生风险。
Objective To investigate the correlation between thyroid peroxidase antibody(TPOAb) and preeclampsia in the second trimester.Method A total of 88 patients were screened for the diagnosis and exclusion criteria of our hospital,including 23 cases of TPOAb positive pregnant women and 65 cases of TPOAb negative JiaJian patients.In the meantime,80 normal pregnant women were chosen as a control group,with their hyroid hormone levels and some index of liver and kidney function test retrospectively analyzed.Data relevant to the number of preeclampsia patients with clinical symptoms in the second trimester were gathered and analyzed.Results Compared with the control group,TPOAb positive group and TPOAb negative group were significantly lower in FT3 and FT4.Besides,TSH,TPOAb,SBP and DBP levels were significantly increased,which presented a statistically significant difference(P<0.05);In comparison with the control group,TPOAb positive group and TPOAb negative group showed an apparently higher level in SBP,DBP,Alanine aminotransferase(ALT),Glutamate transaminase(AST),Creatinine(CRE),Urea nitrogen(BUN),Cystatin C(CYSC) and Blood sugar(GLU),with statistically significant difference(P<0.05);when compared,TPOAb positive JiaJian group and TPOAb negative JiaJian group posed higher chances of preeclampsia symptoms such as proteinuria,hypertension,edema,urine sugar(+),abnormal liver enzymes,and platelets.Conclusion Positive TPOAb JiaJian pregnant women in second trimester are more likely to suffer from preeclampsia symptoms,and thus should have their thyroid function monitored timely and regularly and their drug doses adjusted,to improve the thyroid function and consequently lower the risk of severe preeclampsia.
作者
周利平
高建军
ZHOU Li-ping;GAO Jian-jun(Clinical Laboratory of the people's hospital of Daye, Hubei, Daye 435100, China)
出处
《吉林医学》
CAS
2019年第3期459-462,共4页
Jilin Medical Journal
