摘要
目的:分析与细胞黏附相关的E-cadherin、MUC1及PINCH在非小细胞肺癌(NSCLC)中表达水平,并探讨三者之间的相关性,探寻NSCLC病变进展更具代表性的指标。方法:通过免疫组化法检测70例非小细胞肺癌患者E-cadherin、MUC1及PINCH的表达情况并结合临床分期及有无淋巴结转移进行统计学分析,并探讨三者之间的相关性。结果:NSCLC肿瘤组织中E-cadherin、MUC1及PINCH蛋白的阳性表达率分别是25. 7%、57. 1%和62. 9%,与对照组相比差异具有统计学意义(P<0. 01); E-cadherin阳性表达率随着临床分期的升高而下降(P<0. 01),而MUC1和PINCH阳性表达率随着分期的升高而升高(P<0. 01);有淋巴结转移的肺癌组织中E-cadherin阳性表达率较无淋巴结转移者显著降低(P<0. 05),而有淋巴结转移的肺癌组织中MUC1和PINCH阳性表达率较无淋巴结转移者显著升高(P<0. 05); NSCLC肿瘤组织中MUC1与PINCH的表达水平呈正相关(r=0. 589,P<0. 01),MUC1、PINCH的表达水平与E-cadherin呈负相关(相关系数r值分别为-0. 562,-0. 415,P值均<0. 01)。结论:E-cadherin,MUC1及PINCH三者可能互相联系共同影响细胞间的黏附性进而促进NSCLC的进展;同时检测三者在NSCLC癌组织中的表达,对于探寻NSCLC病变进展更具代表性的指标可能有重要意义。
Objective:To examine the expression of E-cadherin,Mucins1(MUC1)and PINCH in non-small cell lung cancer(NSCLC),and to analyze their correlation.Methods:The expression of E-cadherin Mucins1(MUC1)and PINCH were detected by in 70 primary NSCLC samples by immunohistochemistry method,and their correlation then analyzed.Results:The expression of E-cadherin(25.7%)was remarkably decreased in NSCLC tissues,while the expression of MUC1 and PINCH(57.1%and 62.9%respectively)was remarkably increased(P<0.01).E-cadherin,MUC1 and PINCH expression in NSCLC were related to clinical stage and lymphatic metastasis(P<0.05).The expression of MUC1 and PINCH were positively correlated with the expression of MUC1 and PINCH(r=0.589,P<0.01),and E-cadherin was negative correlation with them(r was-0.562 and-0.415 respectively,P<0.01).Conclusion:E-cadherin,MUC1 and PINCH may interrelated mutually on cell-adhesion,and further promote the progress of NSCLC.Detecting this three protein in NSCLC cancer,may have important significance for the invasion and metastasis in NSCLC.
作者
胡兆鹏
郭丽霞
李慧明
徐妍
梁贺
HU Zhao-Peng;GUO Li-Xia;LI Hui-Ming;XU Yan;LIANG He(Department of Pathology,Pingxiang people′s Hospital,Pingxiang 337000,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2019年第1期88-90,95,共4页
Chinese Journal of Immunology
基金
江西省卫生计生委科技计划项目(20167177)
