摘要
目的评估药物涂层球囊(drug coated balloon,DCB)治疗下肢动脉硬化闭塞症的安全性和效果。方法选择下肢动脉硬化闭塞症患者94例,随机分成2组,对照组46例采用常规球囊扩张+支架成形术,治疗组48例采用美敦力公司DCB球囊扩张,必要时给予支架成形术,术后6个月和12个月以DSA随访,比较2组病变血管晚期管腔丢失、再狭窄率、再次血运重建率、恶性事件发生率。结果随访6个月时,治疗组病变血管晚期管腔丢失少于对照组,差异有统计学意义(P<0.05);2组再狭窄率、再次血运重建率、恶性事件发生率差异均无统计学意义(P>0.05)。随访12个月时,治疗组病变血管晚期管腔丢失少于对照组,治疗组再狭窄率小于对照组,差异均有统计学意义(P<0.05);而2组再次血运重建率、恶性事件发生率差异均无统计学意义(P>0.05)。结论 DCB球囊治疗下肢动脉硬化性闭塞症远期效果良好,可明显降低术后12个月时的病变血管管腔丢失、再狭窄率。
Objective To evaluate the safety and efficacy of drug coated balloon(DCB)in the treatment of arteriosclerosis obliterans of lower extremities.Methods The 94 cases of lower extremity arteriosclerosis obliterans were randomly divided into 2 groups,46 cases in the control group treated with conventional balloon dilatation plus stenting,48 cases in the treatment group expanded by Medtronic Inc DCB balloon,and stent plasty was given when necessary.The patients were followed up for 6 months and 12 months after the operation to compare the late vascular lumen loss in the 2 groups.The late lumen loss,restenosis rate,revascularization rate and incidence of malignant events were compared between the 2 groups.Results After 6 months of followup,the loss of advanced vascular lumen in the treatment group was less than that of the control group.The difference was statistically significant(P<0.05),and there was no significant difference in the restenosis rate,revascularization rate and the incidence of malignant events between the 2 groups(P>0.05).After 12 months of follow up,the loss of advanced vascular lumen in the treatment group was less than that of the control group.The restenosis rate of the treatment group was less than that of the control group,the difference was statistically significant(P<0.05),but the revascularization rate and the incidence of malignant events in the 2 groups were not statistically significant(P>0.05).Conclusion DCB balloon has a good longterm effect in the treatment of arteriosclerotic occlusive disease of the lower extremities.It can obviously reduce the loss of vascular lumen and restenosis rate at 12 months after operation.
作者
张军
林瑞敏
刘军
陈占
张在兴
欧云崧
ZHANG Jun;LIN Rui-min;LIU Jun;CHEN Zhan;ZHANG Zai-xing;OU Yun-song(Department of Vascular Surgery,Beijing Haidian Hospital,Beijing 100080,China)
出处
《河北医科大学学报》
CAS
2019年第2期178-180,197,共4页
Journal of Hebei Medical University
