摘要
目的:探究EASI导联与血清心型脂肪酸结合蛋白(H-FABP)、缺血修饰清蛋白(IMA)联合检测在冠心病心肌缺血病人诊断中的意义。方法:将2016年3月～2018年6月来我院治疗的106例冠心病心肌缺血患者作为观察组,将同期于我院体检的106例健康成年人定义为对照组。比较两组心电图异常率、血清H-FABP、IMA,单项及联合检测诊断冠心病心肌缺血的诊断效能﹑不同联合检测的ROC曲线下面积。结果:观察组心电图异常率及血清H-FABP﹑IMA水平高于对照组(χ~2=59.483,P=0.000;t=36.306,P=0.000;t=42.837,P=0.000);单独EASI导联﹑血清H-FABP﹑IMA诊断冠心病心肌缺血特异度有统计学差异(χ~2=6.134,P=0.047),H-FABP的诊断特异度高于EASI导联、血清IMA(χ~2=4.151,P=0.042;χ~2=5.403,P=0.020);不同平行联合检测诊断冠心病心肌缺血敏感度﹑阴性预测值有统计学差异(χ~2=43.318,P=0.000;χ~2=23.424,P=0.000),不同系列联合检测诊断冠心病心肌缺血特异度有统计学差异(χ~2=9.969,P=0.007);平行联合检测时EASI导联+H-FABP、HFABP+IMA、EASI导联+H-FABP+IMA的ROC曲线下面积分别为0.713、0.782和0.914,系列联合检测ROC曲线下面积分别为0.709、0.724和0.883,EASI导联+H-FABP+IMA的ROC曲线下面积高于EASI导联+H-FABP、H-FABP+IMA(P<0.05)。结论:EASI导联与血清H-FABP﹑IMA联合对于诊断冠心病心肌缺血具有重要意义,可以考虑在临床工作中联合应用。
Objective: To explore the significance of combined detection of EASI lead and serum H-FABP, IMA in the diagnosis of coronary heart disease patients with myocardial ischemia. Methods: The 106 patients with myocardial ischemia of coronary heart disease treated in our hospital from March 2016 to June 2018 were taken as observation group and 106 healthy adults who were examined in our hospital at the same time were defined as control group. The abnormal rate of electrocardiogram (ECG), serum H-FABP and IMA in them, the diagnostic efficacy of single and combined detection in diagnosing myocardial ischemia of coronary heart disease and the area under ROC curve of different joint detection were compared. Results: The abnormal rate of ECG, serum H-FABP and IMA levels in the observation group were higher than those in the control group(χ^2=59.483, P=0.000; t =36.306, P=0.000; t =42.837, P=0.000). The specificity of EASI lead, serum H-FABP and IMA in the diagnosis of coronary heart disease patients with myocardial ischemia was different(χ^2=6.134, P=0.047), the diagnostic specificity of H-FABP was higher than that of EASI lead and serum IMA(χ^2=4.151, P=0.042;χ^2=5.403, P=0.020). The sensitivity and negative predictive value of different parallel combined detection in diagnosing coronary heart disease were different(χ^2=43.318, P=0.000;χ^2=23.424, P=0.000). The specificity of different series of combined detection in the diagnosis of coronary heart disease was different(χ^2=9.969, P=0.007). The areas under ROC curve of EASI lead + H-FABP, H-FABP + IMA and EASI lead + H-FABP + IMA were 0.713,0.782 and 0.914, respectively, and the areas under ROC curve of series of combined detection were 0.709, 0.724 and 0.883, respectively. The area under the ROC curve of EASI lead + H-FABP + IMA was higher than that of EASI lead+H-FABP and H-FABP+IMA( P<0.05). Conclusion: The combination of EASI lead and serum H-FABP and IMA is of great significance in the diagnosis of coronary heart patients with myocardial ischemia. Combined appl
作者
郑丽
朱宏英
冯雪虹
ZHENG Li;ZHU Hong-ying;FENG Xue-hong(Electrocardiogram Room, Wuxi Fifth People's Hospital, Wuxi 214000, Jiangsu, China;Cardiac Ultrasound Room, Wuxi Second People's Hospital, Wuxi 214000, Jiangsu, China)
出处
《海南医学院学报》
CAS
2018年第24期2158-2161,共4页
Journal of Hainan Medical University
基金
无锡市卫生计生委科研项目(QNRC064)~~
