摘要
目的探讨红细胞分布宽度(red blood cell distribution width,RDW)、血红蛋白(hemoglobin,Hb)、血小板平均体积(meam platelet volume,MPV)等血液学指标在胃癌诊断中的价值和意义。方法收集90例原发胃癌、100例体检健康者的外周血标本进行RDW、Hb、MPV等常规血液学指标以及超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)检测。分析这些血液学指标在两组之间的差异,并进一步分析这些指标和胃癌组临床病理参数之间的相关性。结果RDW、Hb、MPV在胃癌患者和健康对照组之间的差异有统计学意义(P <0.05),且RDW在胃癌的分期、最大横截面积、有无远处转移之间的差异也有统计学意义(P <0. 05)。hs-CRP在胃癌术前术后之间差异有统计学意义(P <0.05)。RDW、hs-CRP、MPV也被证明是一个独立的胃癌发生的危险因素(OR=1.457,95%CI 1.113～1.837,P<0.05)。结论 RDW等指标在胃癌的早期诊断中有一定的价值,并对胃癌的分期、转移等也有一定的判断价值。
Objective To investigate the diagnostic value and clinical significance of hematology indexes including the red blood cell distribution width,hemoglobin,mean platelet volume in gastric cancer.Methods We collected peripheral blood specimens of 90 cases of primary gastric cancer and 100 cases of healthy subjects to conduct the routine testing and detection of hematology indexes including RDW,Hb,MPV and hs-CRP.The differences between the two groups were analyzed,and the correlation between these indexes and the clinicopathological parameters of the gastric cancer group was analyzed.Results RDW,Hb and MPV showed significant difference between patients with gastric cancer and the healthy controls(P<0.05).In gastric cancer,RDW showed significant differences in gastric cancer staging,maximum cross-sectional area and distant metastasis(P<0.05).Moreover,RDW,hs-CRP,and MPV were also shown to be independent risk factors for gastric cancer(OR=1.457,95%CI 1.113-1.837,P<0.05).Conclusion RDW and several other indicators have promising diagnosis values in early diagnosis of gastric cancer,as well as in gastric cancer staging and metastasis determination.
作者
钱东林
李翔翔
QIAN Dong-lin;LI Xiang-xiang(Department of Clinical Laboratory,the First People′s Hospital of Wujiang,Suzhou 215000,China)
出处
《标记免疫分析与临床》
CAS
2018年第12期1864-1867,1884,共5页
Labeled Immunoassays and Clinical Medicine
关键词
红细胞分布宽度
胃癌
肿瘤标志物
Red blood cell distribution width
Gastric cancer
Tumor markers
