摘要
肌内脂肪(Intramuscular fat,IMF)是衡量肉品质的重要指标,直接影响肉的嫩度和风味。脂肪细胞分化是受多种细胞因子或信号通路调控的复杂网络体系。IL-33/ST2(Interleukin-33/interleukin-1 receptor like 1)是近年来新发现的具有调控脂肪代谢功能的重要信号通路。综述了IL-33/ST2信号通路成员白介素1受体样1(ST2)变异体及其调控机制、白介素-33 (IL-33)与ST2的相互作用、IL-33/ST2信号通路对白色脂肪米色化、棕色或米色脂肪产热调节的作用机制,旨在为脂肪细胞分化、脂肪沉积相关机制的研究提供参考。
Intramuscular fat(IMF)is an important indicator of meat quality,which can affect the tenderness and flavor of meat.Adipocyte differentiation is a complex network system regulated by multiple cytokines or pathways.IL-33/ST2pathway is an important signaling pathway for regulating fat metabolism in recent years.This article mainly summarizes the research progress of ST2variants and its regulation in IL-33/ST2pathway,IL-33interaction with ST2,effects and mechanism of IL-33/ST2pathway onbeiging of white adipose,brown or beige adipose thermogenesis regulating.The purpose of this review is to provide a reference for the research on the mechanism of adipocyte differentiation and fat deposition.
作者
肖荣
李军
李成萍
郭彦
辛友志
张海燕
周国利
XIAO Rong;LI Jun;LI Chengping;GUO Yan;XIN Youzhi;ZHANG Haiyan;ZHOU Guoli(College of Life Science,Liaocheng University,Liaocheng252059,China;College of Pharmacy,Liaocheng University,Liaocheng252059,China)
出处
《河南农业科学》
CSCD
北大核心
2018年第12期1-6,共6页
Journal of Henan Agricultural Sciences
基金
国家自然科学基金项目(31571274)
山东省自然科学基金项目(ZR2015CM025)
