摘要
目的:探讨氨磺必利与奥氮平对首发精神分裂症患者认知功能的影响。方法:80例首发精神分裂症患者按入组顺序随机分为氨磺必利组及奥氮平组各40例,分别给予氨磺必利和奥氮平治疗8周。在治疗前及治疗8周末分别采用阳性与阴性症状量表(PANSS)、MATRICS公认认知功能成套测验共识版(MCCB)评定疗效及认知功能。结果:治疗后氨磺必利组和奥氮平组PANSS总分及各项评分较治疗前显著下降(P均<0. 01);两组间比较差异无统计学意义(P> 0. 05)。氨磺必利组MCCB的语义流畅(t=-2. 728)、连线测验(t=2. 535)、数字序列(t=-3. 557)、空间广度(t=-2. 550)、言语记忆(t=-4. 378)、视觉记忆(t=2. 236)、情绪管理(t=-4. 701)测验成绩、奥氮平组MCCB的语义流畅(t=-3. 016)、数字序列(t=-2. 613)、空间广度(t=-4. 332)测验成绩与治疗前相比差异有统计学意义(P均<0. 05);两组间相比,氨磺必利组在言语记忆(F=9. 763)、视觉记忆(F=5. 285)及情绪管理(F=7. 960)评分优于奥氮平组(P均<0. 05)。结论:氨磺必利与奥氮平对首发精神分裂症疗效相当,对认知功能均有改善作用,氨磺必利较奥氮平改善的领域更广。
Objective:To explore the effecacy of amisulpride and olanzapine on the cognitive function in first-episode schizophrenia patients.Method:Eighty patients with first-episode schizophrenia were randomly divided into the amisulpride group and olanzapine group according to the order of admission.The treatment course was8weeks.The efficacy and cognitive function of the patients were assessed with the positive and negative syndrome scale(PANSS)and MATRICS consensus cognitive battery(MCCB)before and after8weeks of treatment respectively.Results:After8weeks of treatment,the total scores of PANSS in amisulpride group and olanzapine group were significantly lower than before treatment(all P<0.01),there was no statistically significant difference between the two groups(all P>0.05).In the amisulpride group,the scores after treatment of MCCB category fluency(t=-2.728),trail marking(t=2.535),number sequence(t=-3.557),spatial breadth(t=-2.550),language memory(t=-4.378),visual memory(t=2.236)and emotional management(t=-4.701)and in the olanzapine group,scores of category fluency(t=-3.016)and number sequence(t=-2.613)、spatial breadth(t=-4.332)were statistically different from that before treatment(all P<0.05).There was statistically significant difference between the two groups(all P<0.05),the scores of language memory(F=9.763),visual memory(F=5.285)and emotional management(F=7.960)in the amisulpride group were better than those in the olanzapine group.Conclusion:Amisulpride and olanzapine have equal effecacy on first-episode schizophrenia,they all can improve the cognitive function,amisulpride has more extensive efficacy than olanzapine.
作者
李东霞
吴松杰
马力
魏海燕
胡晓华
LI Dong-xia;WU Song-jie;MA LI;WEI Hai-yan;HU Xiao-hua(Wuhan Mental Health Center,Hubei Province,Wuhan430000,China)
出处
《临床精神医学杂志》
2018年第6期418-420,共3页
Journal of Clinical Psychiatry
