摘要
目的探讨亮菌甲素对急性结石性胆囊炎患者腹腔镜胆囊切除术(LC)后的影响。方法选取急性结石性胆囊炎患者120例,随机分为B组与A组,各60例,两组均予以LC治疗,术后B组予以抗感染治疗,A组在此基础上加用亮菌甲素,连续用药1 w。在治疗术前、术后1 d、术后7 d,检测患者肝功能[包括谷草转氨酶(AST)、血清胆红素(TBIL)],并比较术前和术后7 d两组炎症因子[白介素-6(IL-6)和C反应蛋白(CRP)]等的变化,比较两组恢复情况,包括胃肠功能恢复时间、下床活动时间、住院时间等。结果术后1 d,两组AST、TBIL较术前均显著升高;术后7 d,两组AST、TBIL较术前均显著下降,A组均显著低于B组(P <0.05);术后7 d,两组IL-6、CRP较治疗前均显著下降,且A组显著低于B组(P <0.05);B组胃肠功能恢复时间、下床活动时间、住院时间均显著长于A组(P <0.05)。结论急性结石性胆囊炎患者LC术后采用亮菌甲素治疗,可有效改善肝功能,减轻炎症反应,促进术后康复,值得推广使用。
Objective To explore the impacts of ar^nillarisin on patients with acute gallstone cholecystitis after laparoscopic cholecystectomy(LC).MeAod8 A total of 120 patients with acute gallstone cholecystitis were selected and randomly divided into group A and group B(n=60,respectively).The two groups were treated with LC,after which group B was treated with anti-infective therapy and group A additionally treated with armillarisin for one week.The liver function「including glutamate transaminase(AST)and serum bilirubin(TBIL)1 of patients were detected before and one day and seven days after the operation.The changes in inflammatory factors「interleukin-6(IL-6)and c-reactive protein(CRP)1 before and seven days after the operation were compared between the two groups.The recovery conditions,including gastrointestinal function recovery time,time of off-bed,length of stay(LOS),were compared between the two groups.Results One day after the operation,the levels of AST and TBIL in the two groups were significantly higher than those before the operation;seven days after the operation,the levels of AST and TBIL in the two groups were significantly lower than those before the operation,and the levels in group A were significantly lower than those in group B(P<0.05);seven days after the operation,the levels of IL-6 and CRP were significantly lower than those before the treatment,and the levels in group A were significantly lower than those in group B(P<0.05);the gastrointestinal function recovery time,time of off-bed and LOS in group B were significantly longer than those in group A(P<0.05).Conclusion In the treatment of patients with acute cholecystitis complicated with gallstone after LC,armillarisin can effectively improve liver function,reduce inflammatory reaction and promote postoperative rehabilitation,and is worthy of popularization and application.
作者
崔凯
周子鹏
苏泽满
Cui Kai;Zhou Zipeng;Su Zeman(Department of General Surgery,the Second People's Hospital of Jianli County,Jianli,Hubei,433325,China)
出处
《西南国防医药》
CAS
2018年第12期1163-1165,共3页
Medical Journal of National Defending Forces in Southwest China
