摘要
目的探索血清糖化白蛋白(GA)与内源性分泌型糖基化终产物受体(esRAGE)比值对糖尿病冠状动脉支架内再狭窄风险临床评估的价值。方法选择住院行冠状动脉支架植入术的冠心病合并糖尿病患者共60例(其中男41例、女19例),根据支架术后随访复查冠状动脉造影结果有无支架内再狭窄分成两组:冠心病合并2型糖尿病支架内再狭窄组(再狭窄组,n=25)、冠心病合并2型糖尿病无支架内再狭窄组(无再狭窄组,n=35),分别检测血清esRAGE与GA水平,计算GA/esRAGE比值。结果 esRAGE水平再狭窄组明显低于无再狭窄组(0. 19±0. 07 vs.0. 26±0. 08,P <0. 01),差异有统计学意义。GA/esRAGE比值在再狭窄组明显高于无再狭窄组(1. 26±0. 58 vs. 0. 90±0. 32,P <0. 01),差异有统计学意义。而GA水平在两组间差异无统计学意义(P> 0. 05)。结论 GA与esRAGE比值对预测冠心病合并糖尿病患者支架术后再狭窄有重要临床意义。
Objective To investigate the clinical significance of ratio between glycated albumin(GA)and endogenous secretory receptor of advanced glycation end products(esRAGE)in stent restenosis of coronary artery in diabetic patients.Methods A total of60hospitalized diabetic patients with coronary heart disease(41males,19females)recieving coronary artery stent implantation were include d in September2011to September2014.According to whether there was stent res t enosis in follow-up coronary angiogram,they were divided into two groups:reste nosis group(n=25)and no restenosis group(n=35).Serum levels of GA and e sRAGE were measured and GA/esRAGE ratio was calculated.Results Serum level of esRAGE in restenosis group was significan tly lower than in that in no restenosis group(0.19±0.07vs.0.26±0.08,P<0.01).GA/esRAGE ratio in restenosis group was significantly higher than that in no restenosis group(1.26±0.58v s.0.90±0.32,P<0.01).There was no si gnificant difference in serum GA level between the two groups.Conclusions GA/esRAGE ratio may be a valuable paramter to predict stent restenosis in patient with coronar y heart disease complicated with diabetes.
作者
邬美翠
陆林
林祖近
蔡海鹏
陈磊
WU Mei-cui;LU Lin;LIN Zu-jin(Department of cardiology, Taizhou central hospital, Zhejiang 318000, China)
出处
《心脑血管病防治》
2018年第6期465-468,共4页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
基金
浙江省台州市科学技术局(编号:111KJ07-6)
关键词
内源性分泌型糖化终末产物受体
糖化白蛋白
糖尿病
冠心病
支架内再狭窄
Endogenous secretory receptor of advanced glycation end products
Glycated albumin
Diabetes mellitus
Coronary artery disease
Instent restenosis
