摘要
目的比较静脉滴注与静脉泵注美罗培南治疗神经外科术后肺部感染的临床疗效。方法选取2017年1月—2018年3月在新疆维吾尔自治区人民医院行神经外科手术并发生肺部感染的患者108例,采用随机数字表法分为对照组和观察组,每组54例。在常规治疗基础上,对照组患者给予美罗培南静脉滴注,观察组患者给予美罗培南静脉泵注;两组患者均连续治疗10 d。比较两组患者临床疗效、致病菌清除效果、治疗前及治疗后10 d临床肺部感染量表(CPIS)评分,并观察两组患者治疗期间不良反应发生情况。结果观察组患者临床疗效及致病菌清除效果优于对照组(P<0.05)。治疗前两组患者CPIS评分比较,差异无统计学意义(P>0.05);治疗后10 d观察组患者CPIS评分低于对照组(P<0.05)。两组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论与静脉滴注美罗培南相比,静脉泵注美罗培南能有效提高神经外科术后肺部感染患者临床疗效及致病菌清除效果,减轻肺部感染程度,且安全性较高。
Objective To compare the clinical effect on pulmonary infection after neurosurgical procedures between intravenous drip and intravenous pumping of meropenem.Methods A total of108postoperative pulmonary infection patients underwent neurosurgical procedures were selected in the People's Hospital of Xinjiang Uygur Autonomous Region from January2017to March2018,and they were divided into control group and observation group according to random number table,each of54cases.Based on conventional treatment,patients in control group received intravenous drip of meropenem,while patients in observation group received intravenous pumping of meropenem;both groups continuously treated for10days.Clinical effect,eradication effect of pathogen,CPIS score before treatment and10days after treatment,and incidence of adverse reactions during treatment were compared between the two groups.Results Clinical effect and eradication effect of pathogen in observation group were statistically significantly better than those in control group(P<0.05).No statistically significant differences of CPIS was found between the two groups before treatment(P>0.05),while CPIS score in observation group was statistically significantly lower than that in control group10days after treatment(P<0.05).No statistically significant differences of incidence of adverse reactions was found between the two groups during treatment(P>0.05).Conclusion Compared with intravenous drip of meropenem,intravenous pumping of meropenem can effectively improve the clinical effect and eradication effect of pathogen in postoperative pulmonary infection patients underwent neurosurgical procedures,relieve the severity of pulmonary infection,with relatively high safety.
作者
李方
杜伟
杨乐
李育
LI Fang;DU Wei;YANG Le;LI Yu(Department of Neurosurgery,the People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830011,China)
出处
《实用心脑肺血管病杂志》
2018年第10期78-80,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
感染
肺
美罗培南
静脉滴注
静脉泵入
疗效比较研究
Infection
Lung
Meropenem
Intravenous drip
Intravenous pump
Comparative effectiveness research
