摘要
目的 :观察短肽型肠内营养制剂(enteral nutrition, EN)对急性淋巴细胞白血病(acute lymphoblastic leukemia, ALL)患儿化疗期间营养状况的影响,为ALL患儿化疗提供新的辅助营养治疗方案。方法 :选取50例接受HD-MTX化疗的ALL患儿,随机分为对照组和干预组各25例,均经口进食普通小儿饭,同时干预组额外口服短肽型EN,比较两组患者化疗前后的胃肠道反应和营养状况。结果 :对照组患儿化疗后出现消化道症状者多于干预组(P <0.05),两组患儿化疗后体重无明显变化(P> 0.05),化疗后对照组患儿血清白蛋白(albumin, ALB)、前白蛋白(prealbumin,PA)及转铁蛋白(transferrin, TFN)水平呈下降趋势(P <0.05),而干预组无明显变化(P> 0.05),且化疗后干预组血清ALB、PA、TFN水平显著高于对照组(P <0.05)。结论 :额外补充短肽型EN有助于改善ALL患儿化疗期间的营养状况,减少化疗引起的消化道不良反应。
Objective:To observe the efficiency of short peptide enteral nutrition(EN)on nutritional status during chemotherapy in the children with acute lymphoblastic leukemia(ALL)so as to provide new adjuvant nutrition therapy for their chemotherapy.Methods:Fifty ALL children received high-dose methotrexate(HD-MTX)were randomly divided into a control group and an intervention group with 25 cases each.All children were orally fed with ordinary children’s meals and besides,peptide type EN was orally supplemented in the intervention group.The gastro-intestinal reactions and nutritional status were compared between the two groups before and after chemotherapy.Results:There were more digestive tract symptoms in the control group than in the intervention group(P<0.05).The number of patients with gastrointestinal symptoms after chemotherapy was higher in the control group.There was no significant change in body weight in the two groups(P>0.05).The levels of serum albumin(ALB),prealbumin(PA)and transferrin(TFN)were decreased in the control group after chemotherapy(P<0.05)but not in the intervention group(P>0.05),and the levels of ALB,PA and TFN were significantly higher in the intervention group than the control group(P<0.05).Conclusion:Extra supplement of short peptide type EN can improve the nutritional status of ALL children during chemotherapy and reduce chemotherapy-induced adverse reaction of the digestive tract.
作者
苟芸
杨军红
李凌燕
GOU Yun;YANG Junhong;LI Lingyan(Department of Nutrition,Tianjin Children’s Hospital,Tianjin 300074,China)
出处
《上海医药》
CAS
2018年第23期68-69,73,共3页
Shanghai Medical & Pharmaceutical Journal
关键词
儿童急性淋巴细胞白血病
肠内营养制剂
营养治疗
children acute lymphocytic leukemia
enteral nutrition preparation
nutrition therapy
