摘要
目的探讨三维超声及彩色多普勒超声在乳腺癌新辅助化疗(NAC)疗效评估中的应用价值。方法收集中南大学湘雅医院经病理学证实并行NAC的乳腺癌患者80例,化疗前后均行临床评估(触诊)、二维及三维超声检查,根据化疗前后乳腺肿块变化与病理评估结果进行比较。结果触诊与病理学评估有效率比较,差异有统计学意义(P<0.05)。二维、三维超声评估与病理学评估有效率比较,差异无统计学意义(P>0.05)。NAC后残存肿瘤二维、三维超声测量体积与病理学测量体积均呈正相关(P<0.05)。有效组NAC前后病灶内血流分级变化数、血流阻力指数比较,差异有统计学意义(P<0.05)。结论三维超声评估NAC疗效与病理学评估具有较高的一致性,良好的临床价值可作为乳腺癌NAC疗效评估的有效方法,乳腺癌病灶超声血流信号的变化有助于乳腺癌NAC疗效判断。
Objective To investigate the clinical application value of three-dimensional ultrasonography and color Doppler ultrasonography in the evaluation of neoadjuvant chemotherapy for breast cancer.Methods In this study 80 breast cancer patients confirmed by pathology who received neoadjuvant chemotherapy in Xiangya Hospital of Central South University were collected.Before and after neoadjuvant chemotherapy,all the patients underwent clinical assessment,two-dimensional(2D)ultrasonographic and three-dimensional(3D)ultrasonographic examinations.The results were compared with the pathological evaluation results according to the changes of breast masses.Results There was a significant difference between clinical assessment and pathological assessment(P<0.05).However,the 2D ultrasonographic and 3D ultrasonographic assessments were not significantly different from the pathological assessment(P>0.05).The maximum diameters of the residual tumors after neoadjuvant chemotherapy by 2D and 3D ultrasound measurement were positively correlated with those by pathological evaluation(P<0.05).In the effective group,the differences in the dropping grade of blood flow grading and reduction of blood flow resistance index before and after chemotherapy had statistical significance(P<0.05).Conclusions 3D ultrasonographic assessment has high consistency with pathological evaluation for curative effect of neoadjuvant chemotherapy.The change of ultrasound blood flow signal in breast cancer masses can be helpful to determine the curative effect of neoadjuvant chemotherapy.
作者
彭翅
肖萤
Chi Peng;Ying Xiao(Xiangya Hospital,Central South University,Changsha,Hunan 410008,China)
出处
《中国现代医学杂志》
CAS
2018年第35期78-82,共5页
China Journal of Modern Medicine
关键词
乳腺肿瘤
超声检查
多普勒
彩色
化学疗法
辅助
breast neoplasms
neoadjuvant chemotherapy
ultrasonography,Doppler,color
