摘要
The functional impact of modifications of cellular RNAs,including m RNAs,mi RNAs and lnc RNAs,is a field of intense study.The role of such modifications in cancer has started to be elucidated.Diverse and sometimes opposite effects of RNA modifications have been reported.Some RNA modifications promote,while ot-hers decrease the growth and invasiveness of cancer.The present manuscript reviews the current knowledge on the potential impacts of N6-Methyladenosine,Pse-udouridine,Inosine,2’O-methylation or methylcytidine in cancer’s RNA.It also highlights the remaining qu-estions and provides hints on research avenues and potential therapeutic applications,whereby modulating dynamic RNA modifications may be a new method to treat cancer.
The functional impact of modifications of cellular RNAs, including m RNAs, mi RNAs and lnc RNAs, is a field of intense study. The role of such modifications in cancer has started to be elucidated. Diverse and sometimes opposite effects of RNA modifications have been reported. Some RNA modifications promote, while ot-hers decrease the growth and invasiveness of cancer. The present manuscript reviews the current knowledge on the potential impacts of N6--Methyladenosine, Pse-udouridine, Inosine, 2'-O-methylation or methylcytidine in cancer's RNA. It also highlights the remaining qu-estions and provides hints on research avenues and potential therapeutic applications, whereby modulating dynamic RNA modifications may be a new method to treat cancer.
基金
Supported by University of Zurich:"URPP:Translational Cancer research"
the"MERIT"project supported by the FP7 European Union’s Research
Innovation Funding program
