摘要
目的:探讨孕晚期游离脂肪酸对子痫前期和(或)妊娠期糖尿病(GDM)发病率的影响。方法:选择417例孕晚期子痫前期和(或)GDM为观察组,另选2 018例正常妊娠孕妇为对照组。检测并比较2组血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和游离脂肪酸(FFA)。采用logistic回归模型分析血脂子痫前期和(或)GDM的关系。结果:校正混杂因素[孕妇年龄、孕前体质指数(BMI)和采血时的孕周]后,孕晚期FFA浓度升高会增加子痫前期、GDM和子痫前期合并GDM的风险(P<0.01)。孕晚期TG水平升高会增加子痫前期、GDM发生的风险(P<0.001)。结论:孕晚期FFA水平升高可使子痫前期和(或)GDM发生风险增加。
Objective:To investigate the effect of free fatty acid(FFA)on the incidence of preeclampsia and/or gestational diabetes mellitus(GDM)during late pregnancy.Methods:A total of 417 pregnant women with preeclampsia and/or GDM were selected as the observation group,and another 2 018 normal pregnant women as the control group.The levels of serum lipids including total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),and free fatty acid(FFA)were measured and compared between the two groups.The association between lipid metabolism and pregnancy complications were analyzed by logistic regression models.Results:After adjusting for confounding factors,including pre-pregnancy body mass index(BMI),maternal age and gestational age at blood sampling,FFA concentrations measured during late pregnancy were associated with a significantly increased risk of preeclampsia,GDM and composite of preeclampsia and GDM(P<0.01).Furthermore,elevated maternal TG levels increased the risk of preeclampsia(P<0.001).Conclusions:FFA levels during late pregnancy show strong relationships with the incidence of preeclampsia or GDM.
作者
张瑞晴
徐先明
张佳荣
ZHANG Rui-qing;XU Xian-ming;ZHANG Jia-rong(Department of Obstetrics and Gynecology,Shanghai General Hospital,Shanghai 200032,China)
出处
《中国临床医学》
2018年第5期720-723,共4页
Chinese Journal of Clinical Medicine
基金
上海市女性生殖内分泌相关疾病重点实验室开放课题(14DZ2271700)
"研究型医师"以及"临床专职科研队伍"项目(20172020)~~
关键词
游离脂肪酸
三酰甘油
妊娠期糖尿病
子痫前期
free fatty acids
triglyceride
gestational diabetes mellitus
preeclampsia
