摘要
骨关节炎是临床常见病,也是难治疾病之一,因其软骨损伤后较难修复。不同的信号通路对软骨代谢具有调节作用,笔者列举了软骨代谢中3条经典通路Notch、Wnt及MAPK信号通路,并阐述分析了Notch、Wnt及MAPK信号通路对不同时期软骨细胞代谢,以及软骨受损时软骨代谢的影响。同时,总结了运动对受损关节软骨的影响及作用机制,为运动治疗骨关节炎提供一定理论参考。
Osteoarthritis(OA)is common clinical disease,and it is one of the diseases hard to treat,because the chondrocyte is difficult to repair after being damaged.Different signaling pathways regulate chondrocyte metabolism,and this paper listed three classic pathways,Notch,Wnt and MAPK signaling pathways,elaborated and analyzed their function during the different periods of chondrocyte metabolism and on inflammation and oxidative stress.Meanwhile,we summarized the effect of exercise on the damaged cartilage,in order to provide reference basis of exercise therapy on OA.
作者
吴伟
焦俊玥
李慧
张玲莉
WU Wei;JIAO Junyue;LI Hui;ZHANG Lingli(Shanghai University of Sport,Shanghai 200438;The 3rd Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou 310053,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2018年第10期1384-1389,共6页
Chinese Journal of Osteoporosis
基金
上海市人类运动能力开发与保障重点实验室(上海体育学院)资助课题(11DZ2261100)
关键词
骨关节炎
软骨代谢
信号通路
运动
osteoarthritis
chondrocyte metabolism
signaling pathway
exercise
