摘要
目的建立新的nomogram提高妊娠女性子痫前期(PE)发生的预测效率,并以受试者工作曲线(ROC)对其进行评价。方法回顾性分析2015年1月至2016年12月在医院建卡并分娩的642例疑似子痫前期孕妇。记录胎盘生长因子(PLGF)、D-二聚体、可溶性血管内皮生长因子受体-1(s Flt-1)、血清胱抑素C(Cys C)、年龄及体重指数(BMI)等多个临床指标。采用多元逻辑回归分析筛选有显著性因素建立新的nomogram。建立ROC曲线比较新的nomogram与单独因素的诊断效率。结果 PE发病总例数106例,总发病率16. 5%。最终年龄、PLGF、D-二聚体、s Flt-1、Cys C共5个变量显示了多因素显著性,并纳入新的nomogram。新nomogram的曲线下面积为0. 937,显著高于各单项指标。结论本研究联合年龄、PLGF、D-2、s Flt-1、Cys C建立nomogram评估PE发生率,准确性较高,且各项指标均为临床常用检查项目,易于推广。
Objective To establish an new nomogram to improve the accuracy of preeclampsia(PE)detection in pregnant women,and to evaluate the value of the new nomogram by means of ROC.Methods The clinical data about 642 pregnant women with suspected preeclampsia who were admitted and treated in our hospital from January 2015 to December 2016 were retrospectively analyzed.Moreover age,PLGF,D-2,sFlt-1,Cys C and BMI were statistically analyzed by means of Logistic regression,and ROC curve was set up to compare the diagnistic efficiency between the new nomogram and single factor.Results The total incidence of PE was 106 cases and total incidence rate was 16.5%.The 5 variables including the final age,PLGF,D-2,sFlt-1,Cys C showed multifactor significance,which was included in the new nomogram.The area under curve(AUC)of new nomogram was 0.937,which was significantly higher than that in every single index.Conclusion An new simple and convenient nomogram is established,which has higher accuracy in evaluating the incidence of PE in pregnant women.
作者
张悦
杨青
李蕊
贾幸花
娄娟
张丽宏
ZHANG Yue;YANG Qing;LI Rui;JIA XINGhua;LOU Juan;ZHANG Lihong(Qinhuangdao Hospital for Maternal and Child Health,Hebei,Qinhuangdao 066000,China)
出处
《河北医药》
CAS
2018年第21期3316-3318,共3页
Hebei Medical Journal
关键词
子痫前期
胎盘生长因子
列线图
ROC曲线
preeclampsia
placenta growth factor
nomogram
receiver operating characteristic curve
