摘要
目的探究苏州市0-6岁儿童骨密度养状况和影响因素及其与25羟维生素D关系,为预防儿童骨密度不足提供科学依据。方法选择苏州地区0-6岁儿童481名作为研究对象进行体格测量和相关问卷调查,并采用免疫层析法测定血清25羟维生素D水平和应用定量超声仪检测骨密度。结果 (1)定量超声骨密度Z值平均水平为-0.03±0.87,骨密度不足者57名(11.90%)。(2)单因素分析结果显示年龄(χ~2=10.38,P<0.001)、肉类(t=3.01,P=0.003)摄入和蛋类摄入(t=2.15,P=0.036)、睡眠时间(χ~2=8.63,P=0.013)、BMI(χ~2=11.89,P=0.003)、维生素D营养状况(χ~2=18.37,P<0.001)与儿童骨密度水平有关。(3)二元logistic回归分析显示肥胖(BMI>18)是影响儿童骨密度危险因素(OR=4.730,P=0.003),维生素D充足是其保护因素(OR=0.133,P<0.001)。(4)血清25羟维生素D水平和骨密度值之间存在正性直线相关关系(P<0.001)。结论 1岁内婴儿是防治儿童骨强度不足主要人群,且学龄前儿童骨密度监测工作不可忽视。防治肥胖和合理维生素D补充有利于提高儿童骨密度,促进骨骼健康发展。
Objective To investigate the status of bone mineral density(BMD)among 0-6 years old children in Suzhou,and its influencing factors and the relationship with 25-hydroxyvitamin D,which could provide scientific evidence for preventing BMD deficiency in children.Methods A total of 481 healthy 0-6 years old children were recruited from Suzhou.Anthropometric indices and the related questionnaire investigation were conducted among all the participants.Serum 25-hydroxyvitamin D level was measured using colloidal gold immunochromatography and BMD was measured using quantitative ultrasound.Results (1)The means and standard deviations of Z-scores were-0.03±0.87.Fifty-seven children(11.9%)had BMD deficiency.(2)Univariate analysis revealed that age(χ2=10.38,P<0.001),meat(t=3.01,P=0.003),egg(t=2.15,P=0.036)consumption per week,sleeping time(χ2=8.63,P=0.013),BMI(χ2=11.89,P=0.003),and vitamin D status(χ2=18.37,P<0.001)were associated with BMD.(3)The result of bivariate regression analysis showed that obesity(BMI>18)was the risk factor of BMD(OR=4.730,P=0.003).Meanwhile,the protective factor of BMD was vitamin D status(OR=0.133,P<0.001).(4)There was a positive linear correlation between 25-hydroxyvitamin D and BMD(P<0.001).Conclusion The infants aged 0-1 years old are the most important population of BMD deficiency.It could not to be ignored to monitor BMD deficiency among preschoolers.Prevention and treatment of obesity and appropriate vitamin D supplementation may be beneficial to improve BMD and to promote bone health.
作者
孔锐
宋媛
叶侃
孟玉梅
周琴
KONG Rui;SONG Yuan;YE Kan;MENG Yumei;ZHOU Qin(Department of Child Health,Suzhou Municipal Hospital,Suzhou 215002,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2018年第9期1219-1224,共6页
Chinese Journal of Osteoporosis
基金
苏州市科技局项目(SYSD2017104)
