摘要
目的:了解门诊处方中氯吡格雷合并用药情况,为其临床合理用药提供参考和依据。方法:调取河北省人民医院2017年1月1日到2月28日所有含有氯吡格雷的门诊处方,选取与氯吡格雷联合用药的处方进行整理和统计,基于细胞色素P450酶(CYP3A4、CYP2C19)角度分析处方中与氯吡格雷存在潜在的药物相互作用的药物。结果:含有氯吡格雷的门诊处方共计1 757张,联合用药的处方有1 732张,其中存在潜在的代谢性药物相互作用的处方有871张,主要涉及质子泵抑制剂(抑制CYP2C19活性)与他汀类药物(抑制CYP3A4活性)。结论:在临床中,氯吡格雷与其他药物联合使用情况较普遍,存在潜在的代谢性药物相互作用。
OBJECTIVE:To investigate the drug combination of clopidogrel in outpatient prescriptions,and to provide reference and evidence for rational drug use in clinic.METHODS:The outpatient prescriptions of clopidogrel were collected from Hebei Provincial People’s Hospital during Jan.1st-Feb.28th in 2017.The prescriptions of clopidogrel drug combination were collated and counted.Based on the respective of CYP450 enzyme(CYP3A4,CYP2C19),drugs with potential drug interaction with clopidogrel in prescriptions were analyzed.RESULTS:There were 1 757 outpatient prescriptions of clopidogrel,involving 1 732 prescriptions of drug combination.There were 871 prescriptions of the potential metabolizing drug-drug interaction,mainly involving proton pump inhibitors(inhibiting the activity of CYP2C19)and statins(inhibiting the activity of CYP3A4).CONCLUSIONS:Clopidogrel is commonly used in combination with other drugs in clinical practice,and there is a potential metabolic drug interaction.
作者
宋浩静
杜亚斌
郭彩会
孙雪
支旭然
董占军
SONG Haojing;DU Yabin;GUO Caihui;SUN Xue;ZHI Xuran;DONG Zhanjun(Dept.of Pharmacy,Hebei General Hospital,Shijiazhuang 050051,China;Dept.of Urology Surgery,Bethune International Peace Hospital of PLA,Shijiazhuang 050081,China)
出处
《中国药房》
CAS
北大核心
2018年第17期2429-2432,共4页
China Pharmacy
基金
河北省医学科学研究重点课题计划(No.20150132)
